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DOI: 10.1055/s-0036-1578645
Improving Sample Preparation Methods For Cannabis-Infused Edible And Topical Products
With implementation of medical marijuana programs in 34 US states, new cannabis products are being developed at a rapid pace, challenging quality control chemists to quickly develop analytical methods to comply with testing requirements. Traditional extraction methods don't always work with complex food or topical matrices. Problems such as non-homogenous samples can lead to inaccurate measurements when using traditional solvent based extraction methods. In addition, large amounts of chlorinated solvents are often needed.
Flash chromatography has been employed to address these challenges by isolating cannabinoids away from interfering compounds (fat, sugar, salts, etc) present in the matrix before analysis, and ensuring a homogenous extraction process. The authors show successful application of the methodology to analysis of several cannabis-infused products: brownies, gummy candies, caramels, and lotion.