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Neuropediatrics 2016; 47(03): 139-150
DOI: 10.1055/s-0036-1572411
DOI: 10.1055/s-0036-1572411
Review Article
Treatment of Infantile Spasms: Report of the Interdisciplinary Guideline Committee Coordinated by the German-Speaking Society for Neuropediatrics
Weitere Informationen
Publikationsverlauf
15. Dezember 2015
24. Dezember 2015
Publikationsdatum:
24. Februar 2016 (online)
Abstract
Objectives This report aims to define treatment goals, to summarize the evidence level (EL) of different treatment options for infantile spasms (IS), both in terms of efficacy and adverse effect, and to give recommendations for the management of IS.
Methods The Cochrane and Medline (1966–July 2014) databases were searched. Literature known to the guideline working group and identified through citations was also considered. The results of previously published guidelines were taken into account in our analysis. Rating the level of evidence followed the Scottish Intercollegiate Guidelines Network.
Recommendations If IS are suspected, electroencephalogram (EEG) should be performed within a few days and, if confirmed, treatment should be initiated immediately. Response to first-line treatments should be evaluated clinically and electroencephalographically after 14 days.
Adrenocorticotropic hormone, corticosteroids, and vigabatrin are the first-line drugs for the treatment of IS. In children with tuberous sclerosis complex, vigabatrin is the treatment of first choice. Ketogenic diet, sulthiame, topiramate, valproate, zonisamide, and benzodiazepines can be used when first-line drugs have proved ineffective. Children refractory to drug therapy should be evaluated for epilepsy surgery, especially if focal brain lesions are present.
Regular follow-up controls, including EEG (preferably sleep EEG) and standardized developmental assessment are recommended.
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References
- 1 Lux AL, Osborne JP. A proposal for case definitions and outcome measures in studies of infantile spasms and West syndrome: consensus statement of the West Delphi group. Epilepsia 2004; 45 (11) 1416-1428
- 2 Frost Jr JD, Hrachovy RA. Infantile Spasms. Diagnosis, Management and Prognosis. Boston, MA: Kluwer Academic Publishers; 2003
- 3 Lux AL, Edwards SW, Hancock E , et al; United Kingdom Infantile Spasms Study. The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial. Lancet Neurol 2005; 4 (11) 712-717
- 4 Mackay MT, Weiss SK, Adams-Webber T , et al; American Academy of Neurology; Child Neurology Society. Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. Neurology 2004; 62 (10) 1668-1681
- 5 Go CY, Mackay MT, Weiss SK , et al; Child Neurology Society; American Academy of Neurology; Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Evidence-based guideline update: medical treatment of infantile spasms. Neurology 2012; 78 (24) 1974-1980
- 6 Hancock EC, Osborne JP, Edwards SW. Treatment of infantile spasms. Cochrane Database Syst Rev 2013; 6: CD001770
- 7 Hrachovy RA, Glaze DG, Frost Jr JD. A retrospective study of spontaneous remission and long-term outcome in patients with infantile spasms. Epilepsia 1991; 32 (2) 212-214
- 8 Appleton RE, Peters AC, Mumford JP, Shaw DE. Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms. Epilepsia 1999; 40 (11) 1627-1633
- 9 National Programme for Disease Management Guidelines. Method Report, 4th edition. Version 1.0–30 July 2010. Available at: http://www.leitlinien.de/mdb/downloads/nvl/methodik/mr-engl-aufl-4-version-1.pdf . Accessed January 28, 2016
- 10 Hrachovy RA, Frost Jr JD, Kellaway P, Zion TE. Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr 1983; 103 (4) 641-645
- 11 Dreifuss F, Farwell J, Holmes G , et al. Infantile spasms. Comparative trial of nitrazepam and corticotropin. Arch Neurol 1986; 43 (11) 1107-1110
- 12 Hrachovy RA, Frost Jr JD, Glaze DG. High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. J Pediatr 1994; 124 (5 Pt 1) 803-806
- 13 Baram TZ, Mitchell WG, Tournay A, Snead OC, Hanson RA, Horton EJ. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics 1996; 97 (3) 375-379
- 14 Vigevano F, Cilio MR. Vigabatrin versus ACTH as first-line treatment for infantile spasms: a randomized, prospective study. Epilepsia 1997; 38 (12) 1270-1274
- 15 Yamamoto H, Asoh M, Murakami H, Kamiyama N, Ohta C. Liposteroid (dexamethasone palmitate) therapy for West syndrome: a comparative study with ACTH therapy. Pediatr Neurol 1998; 18 (5) 415-419
- 16 Yanagaki S, Oguni H, Hayashi K , et al. A comparative study of high-dose and low-dose ACTH therapy for West syndrome. Brain Dev 1999; 21 (7) 461-467
- 17 Lux AL, Edwards SW, Hancock E , et al. The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial. Lancet 2004; 364 (9447) 1773-1778
- 18 Shu XM, Li J, Zhang GP, Mao Q. [A comparative study of conventional dose and low dose adrenocorticotrophic hormone therapy for West syndrome]. Zhongguo Dang Dai Er Ke Za Zhi 2009; 11 (6) 445-448
- 19 Zhu X, Chen O, Zhang D , et al. A prospective study on the treatment of infantile spasms with first-line topiramate followed by low-dose ACTH. Epilepsy Res 2011; 93 (2–3) 149-154
- 20 Darke K, Edwards SW, Hancock E , et al; trial steering committee on behalf of participating investigators. Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial. Arch Dis Child 2010; 95 (5) 382-386
- 21 O'Callaghan FJ, Lux AL, Darke K , et al. The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: evidence from the United Kingdom Infantile Spasms Study. Epilepsia 2011; 52 (7) 1359-1364
- 22 Wanigasinghe J, Arambepola C, Sri Ranganathan S, Sumanasena S, Muhandiram EC. The efficacy of moderate-to-high dose oral prednisolone versus low-to-moderate dose intramuscular corticotropin for improvement of hypsarrhythmia in West syndrome: a randomized, single-blind, parallel clinical trial. Pediatr Neurol 2014; 51 (1) 24-30
- 23 Hrachovy RA, Frost Jr JD, Kellaway P, Zion T. A controlled study of ACTH therapy in infantile spasms. Epilepsia 1980; 21 (6) 631-636
- 24 Lombroso CT. A prospective study of infantile spasms: clinical and therapeutic correlations. Epilepsia 1983; 24 (2) 135-158
- 25 Glaze DG, Hrachovy RA, Frost Jr JD, Kellaway P, Zion TE. Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone. J Pediatr 1988; 112 (3) 389-396
- 26 Snead III OC, Benton Jr JW, Hosey LC , et al. Treatment of infantile spasms with high-dose ACTH: efficacy and plasma levels of ACTH and cortisol. Neurology 1989; 39 (8) 1027-1031
- 27 Bobele GB, Ward KE, Bodensteiner JB. Hypertrophic cardiomyopathy during corticotropin therapy for infantile spasms. A clinical and echocardiographic study. Am J Dis Child 1993; 147 (2) 223-225
- 28 Kusse MC, van Nieuwenhuizen O, van Huffelen AC, van der Mey W, Thijssen JH, van Ree JM. The effect of non-depot ACTH(1-24) on infantile spasms. Dev Med Child Neurol 1993; 35 (12) 1067-1073
- 29 Heiskala H, Riikonen R, Santavuori P , et al. West syndrome: individualized ACTH therapy. Brain Dev 1996; 18 (6) 456-460
- 30 Takuma Y, Seki T. Combination therapy of infantile spasms with high-dose pyridoxal phosphate and low-dose corticotropin. J Child Neurol 1996; 11 (1) 35-40
- 31 Zafeiriou DI, Kontopoulos EE, Tsikoulas IG. Adrenocorticotropic hormone and vigabatrin treatment of children with infantile spasms underlying cerebral palsy. Brain Dev 1996; 18 (6) 450-452
- 32 Oguni H, Yanagaki S, Hayashi K , et al. Extremely low-dose ACTH step-up protocol for West syndrome: maximum therapeutic effect with minimal side effects. Brain Dev 2006; 28 (1) 8-13
- 33 Hussain SA, Shinnar S, Kwong G , et al. Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone. Epilepsia 2014; 55 (1) 103-107
- 34 Bower BD, Jeavons PM. The effect of corticotrophin and prednisolone on infantile spasms with mental retardation. Arch Dis Child 1961; 36 (185) 23-33
- 35 Riikonen R, Donner M. ACTH therapy in infantile spasms: side effects. Arch Dis Child 1980; 55 (9) 664-672
- 36 Singer WD, Rabe EF, Haller JS. The effect of ACTH therapy upon infantile spasms. J Pediatr 1980; 96 (3 Pt 1) 485-489
- 37 Matsumoto A, Watanabe K, Negoro T , et al. Long-term prognosis after infantile spasms: a statistical study of prognostic factors in 200 cases. Dev Med Child Neurol 1981; 23 (1) 51-65
- 38 Lerman P, Kivity S. The efficacy of corticotropin in primary infantile spasms. J Pediatr 1982; 101 (2) 294-296
- 39 Riikonen R. A long-term follow-up study of 214 children with the syndrome of infantile spasms. Neuropediatrics 1982; 13 (1) 14-23
- 40 Snead III OC, Benton JW, Myers GJ. ACTH and prednisone in childhood seizure disorders. Neurology 1983; 33 (8) 966-970
- 41 Fois A, Malandrini F, Balestri P, Giorgi D. Infantile spasms—long term results of ACTH treatment. Eur J Pediatr 1984; 142 (1) 51-55
- 42 Ito M, Okuno T, Fujii T , et al. ACTH therapy in infantile spasms: relationship between dose of ACTH and initial effect or long-term prognosis. Pediatr Neurol 1990; 6 (4) 240-244
- 43 Riikonen R, Simell O. Tuberous sclerosis and infantile spasms. Dev Med Child Neurol 1990; 32 (3) 203-209
- 44 Sher PK, Sheikh MR. Therapeutic efficacy of ACTH in symptomatic infantile spasms with hypsarrhythmia. Pediatr Neurol 1993; 9 (6) 451-456
- 45 Cossette P, Riviello JJ, Carmant L. ACTH versus vigabatrin therapy in infantile spasms: a retrospective study. Neurology 1999; 52 (8) 1691-1694
- 46 Ito M, Aiba H, Hashimoto K , et al. Low-dose ACTH therapy for West syndrome: initial effects and long-term outcome. Neurology 2002; 58 (1) 110-114
- 47 Hamano S, Tanaka M, Mochizuki M, Sugiyama N, Eto Y. Long-term follow-up study of West syndrome: Differences of outcome among symptomatic etiologies. J Pediatr 2003; 143 (2) 231-235
- 48 Kivity S, Lerman P, Ariel R, Danziger Y, Mimouni M, Shinnar S. Long-term cognitive outcomes of a cohort of children with cryptogenic infantile spasms treated with high-dose adrenocorticotropic hormone. Epilepsia 2004; 45 (3) 255-262
- 49 Kondo Y, Okumura A, Watanabe K , et al. Comparison of two low dose ACTH therapies for West syndrome: their efficacy and side effect. Brain Dev 2005; 27 (5) 326-330
- 50 Azam M, Bhatti N, Krishin J. Use of ACTH and prednisolone in infantile spasms: experience from a developing country. Seizure 2005; 14 (8) 552-556
- 51 Hamano S, Yamashita S, Tanaka M, Yoshinari S, Minamitani M, Eto Y. Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: differences in dosage of adrenocorticotropic hormone, onset of age, and cause. J Pediatr 2006; 148 (4) 485-488
- 52 Haberlandt E, Weger C, Sigl SB , et al. Adrenocorticotropic hormone versus pulsatile dexamethasone in the treatment of infantile epilepsy syndromes. Pediatr Neurol 2010; 42 (1) 21-27
- 53 Kossoff EH, Hedderick EF, Turner Z, Freeman JM. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia 2008; 49 (9) 1504-1509
- 54 Peltzer B, Alonso WD, Porter BE. Topiramate and adrenocorticotropic hormone (ACTH) as initial treatment for infantile spasms. J Child Neurol 2009; 24 (4) 400-405
- 55 Cohen-Sadan S, Kramer U, Ben-Zeev B , et al. Multicenter long-term follow-up of children with idiopathic West syndrome: ACTH versus vigabatrin. Eur J Neurol 2009; 16 (4) 482-487
- 56 Ikegami M, Takahashi Y, Ikeda H , et al. [Efficacy of repeated adrenocorticotropic hormone therapy in patients with intractable epileptic spasms]. No To Hattatsu 2013; 45 (4) 281-287
- 57 Ohya T, Nagai T, Araki Y , et al; Research Group on Adverse Effects of Vaccination in Patients with Neurological Disorders. A pilot study on the changes in immunity after ACTH therapy in patients with West syndrome. Brain Dev 2009; 31 (10) 739-743
- 58 Zou LP, Wang X, Dong CH, Chen CH, Zhao W, Zhao RY. Three-week combination treatment with ACTH + magnesium sulfate versus ACTH monotherapy for infantile spasms: a 24-week, randomized, open-label, follow-up study in China. Clin Ther 2010; 32 (4) 692-700
- 59 Sukhudyan BG, Dimova PS, Capuano A, Vigevano F. Dyskinesia as a new adverse effect of hormonal treatment in West syndrome. Epileptic Disord 2014; 16 (1) 5-12
- 60 Hrachovy RA, Frost Jr JD, Kellaway P, Zion T. A controlled study of prednisone therapy in infantile spasms. Epilepsia 1979; 20 (4) 403-407
- 61 Chiron C, Dumas C, Jambaqué I, Mumford J, Dulac O. Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis. Epilepsy Res 1997; 26 (2) 389-395
- 62 Schlumberger E, Dulac O. A simple, effective and well-tolerated treatment regime for West syndrome. Dev Med Child Neurol 1994; 36 (10) 863-872
- 63 Ruf S, Krägeloh-Mann I, Wolff M. Steroid-Puls-Therapie per os: Eine Therapieoption bei Kindern mit pharmakoresistenten Epilepsien. In: Wenzel D, Trollmann R, eds. Aktuelle Neuropädiatrie 2005. Nürnberg: Novartis Pharma Verlag; 2006: 236-240
- 64 Kossoff EH, Hartman AL, Rubenstein JE, Vining EP. High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH. Epilepsy Behav 2009; 14 (4) 674-676
- 65 Mohamed BP, Scott RC, Desai N, Gutta P, Patil S. Seizure outcome in infantile spasms—a retrospective study. Epilepsia 2011; 52 (4) 746-752
- 66 Mytinger JR, Quigg M, Taft WC, Buck ML, Rust RS. Outcomes in treatment of infantile spasms with pulse methylprednisolone. J Child Neurol 2010; 25 (8) 948-953
- 67 Ware TL, Mackay MT, Harvey AS, Freeman JL. Epileptic spasms: experience with a high-dose oral corticosteroid protocol. J Paediatr Child Health 2012; 48 (11) 985-989
- 68 Elterman RD, Shields WD, Mansfield KA, Nakagawa J ; US Infantile Spasms Vigabatrin Study Group. Randomized trial of vigabatrin in patients with infantile spasms. Neurology 2001; 57 (8) 1416-1421
- 69 Askalan R, Mackay M, Brian J , et al. Prospective preliminary analysis of the development of autism and epilepsy in children with infantile spasms. J Child Neurol 2003; 18 (3) 165-170
- 70 Elterman RD, Shields WD, Bittman RM, Torri SA, Sagar SM, Collins SD. Vigabatrin for the treatment of infantile spasms: final report of a randomized trial. J Child Neurol 2010; 25 (11) 1340-1347
- 71 Vles JS, van der Heyden AM, Ghijs A, Troost J. Vigabatrin in the treatment of infantile spasms. Neuropediatrics 1993; 24 (4) 230-231
- 72 Covanis A, Theodorou V, Lada C, Skiadas K, Loli N. The first-line use of vigabatrin to achieve complete control of infantile spasms. J Epilepsy 1998; 11 (5) 265-269
- 73 Wohlrab G, Boltshauser E, Schmitt B. Vigabatrin as a first-line drug in West syndrome: clinical and electroencephalographic outcome. Neuropediatrics 1998; 29 (3) 133-136
- 74 Siemes H, Brandl U, Spohr HL, Völger S, Weschke B. Long-term follow-up study of vigabatrin in pretreated children with West syndrome. Seizure 1998; 7 (4) 293-297
- 75 Fejerman N, Cersósimo R, Caraballo R , et al. Vigabatrin as a first-choice drug in the treatment of West syndrome. J Child Neurol 2000; 15 (3) 161-165
- 76 Nabbout R, Melki I, Gerbaka B, Dulac O, Akatcherian C. Infantile spasms in Down syndrome: good response to a short course of vigabatrin. Epilepsia 2001; 42 (12) 1580-1583
- 77 Aicardi J, Mumford JP, Dumas C, Wood S ; Sabril IS Investigator and Peer Review Groups. Vigabatrin as initial therapy for infantile spasms: a European retrospective survey. Epilepsia 1996; 37 (7) 638-642
- 78 Kwong L. Vigabatrin as first line therapy in infantile spasms: review of seven patients. J Paediatr Child Health 1997; 33 (2) 121-124
- 79 Granström ML, Gaily E, Liukkonen E. Treatment of infantile spasms: results of a population-based study with vigabatrin as the first drug for spasms. Epilepsia 1999; 40 (7) 950-957
- 80 Koo B. Vigabatrin in the treatment of infantile spasms. Pediatr Neurol 1999; 20 (2) 106-110
- 81 Tay SK, Ong HT, Low PS. The use of vigabatrin in infantile spasms in Asian children. Ann Acad Med Singapore 2001; 30 (1) 26-31
- 82 Mitchell WG, Shah NS. Vigabatrin for infantile spasms. Pediatr Neurol 2002; 27 (3) 161-164
- 83 Kankirawatana P, Raksadawan N, Balangkura K. Vigabatrin therapy in infantile spasms. J Med Assoc Thai 2002; 85 (Suppl. 02) S778-S783
- 84 Capovilla G, Beccaria F, Montagnini A , et al. Short-term nonhormonal and nonsteroid treatment in West syndrome. Epilepsia 2003; 44 (8) 1085-1088
- 85 Camposano SE, Major P, Halpern E, Thiele EA. Vigabatrin in the treatment of childhood epilepsy: a retrospective chart review of efficacy and safety profile. Epilepsia 2008; 49 (7) 1186-1191
- 86 Ibrahim S, Gulab S, Ishaque S, Saleem T. Clinical profile and treatment of infantile spasms using vigabatrin and ACTH—a developing country perspective. BMC Pediatr 2010; 10: 1
- 87 Gaily E, Jonsson H, Lappi M. Visual fields at school-age in children treated with vigabatrin in infancy. Epilepsia 2009; 50 (2) 206-216
- 88 Wohlrab G, Leiba H, Kästle R , et al. Vigabatrin therapy in infantile spasms: solving one problem and inducing another?. Epilepsia 2009; 50 (8) 2006-2008
- 89 Riikonen R, Rener-Primec Z, Carmant L , et al. Does vigabatrin treatment for infantile spasms cause visual field defects? An international multicentre study. Dev Med Child Neurol 2015; 57 (1) 60-67
- 90 Desguerre I, Marti I, Valayannopoulos V , et al. Transient magnetic resonance diffusion abnormalities in West syndrome: the radiological expression of non-convulsive status epilepticus?. Dev Med Child Neurol 2008; 50 (2) 112-116
- 91 Milh M, Villeneuve N, Chapon F , et al. Transient brain magnetic resonance imaging hyperintensity in basal ganglia and brain stem of epileptic infants treated with vigabatrin. J Child Neurol 2009; 24 (3) 305-315
- 92 Pearl PL, Vezina LG, Saneto RP , et al. Cerebral MRI abnormalities associated with vigabatrin therapy. Epilepsia 2009; 50 (2) 184-194
- 93 Wheless JW, Carmant L, Bebin M , et al. Magnetic resonance imaging abnormalities associated with vigabatrin in patients with epilepsy. Epilepsia 2009; 50 (2) 195-205
- 94 Simao GN, Zarei Mahmoodabadi S, Snead OC, Go C, Widjaja E. Abnormal axial diffusivity in the deep gray nuclei and dorsal brain stem in infantile spasm treated with vigabatrin. AJNR Am J Neuroradiol 2011; 32 (1) 199-203
- 95 Dill P, Datta AN, Weber P, Schneider J. Are vigabatrin induced T2 hyperintensities in cranial MRI associated with acute encephalopathy and extrapyramidal symptoms?. Eur J Paediatr Neurol 2013; 17 (3) 311-315
- 96 Fong CY, Osborne JP, Edwards SW , et al. An investigation into the relationship between vigabatrin, movement disorders, and brain magnetic resonance imaging abnormalities in children with infantile spasms. Dev Med Child Neurol 2013; 55 (9) 862-867
- 97 Debus OM, Kurlemann G ; Study group. Sulthiame in the primary therapy of West syndrome: a randomized double-blind placebo-controlled add-on trial on baseline pyridoxine medication. Epilepsia 2004; 45 (2) 103-108
- 98 Völzke E, Doose H, Stephan E. The treatment of infantile spasms and hypsarrhythmia with mogadon. Epilepsia 1967; 8 (1) 64-70
- 99 Müller K, Kohlheb O. [Early results (initial effects) of the treatment with mogadan in propulsive petit mal epilepsy]. Z Kinderheilkd 1968; 103 (4) 336-348
- 100 Vassella F, Pavlincova E, Schneider HJ, Rudin HJ, Karbowski K. Treatment of infantile spasms and Lennox-Gastaut syndrome with clonazepam (Rivotril). Epilepsia 1973; 14 (2) 165-175
- 101 Dumermuth G, Kovacs E. The effect of clonazepam (Ro 5-4023) in the syndrome of infantile spasms with hypsarrhythmia and in petit mal variant of Lennox syndrome. Preliminary report. Acta Neurol Scand Suppl 1973; 53: 26-28
- 102 Kotlarek F, Deselaers M, Hotes G. [How effective is the treatment schedule in children with infantile spasms?]. Klin Padiatr 1985; 197 (1) 21-24
- 103 Tatzer E, Groh C, Müller R, Lischka A. Carbamazepine and benzodiazepines in combination—a possibility to improve the efficacy of treatment of patients with ‘intractable’ infantile spasms?. Brain Dev 1987; 9 (4) 415-417
- 104 Chamberlain MC. Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome. J Child Neurol 1996; 11 (1) 31-34
- 105 Fallah R, Salor F, Akhavan Karbasi S, Motaghipisheh H. Randomised clinical efficacy trial of topiramate and nitrazepam in treatment of infantile spasms. Iran J Child Neurol 2014; 8 (1) 12-19
- 106 Ariizumi M, Baba K, Hibio S , et al. Immunoglobulin therapy in the West syndrome. Brain Dev 1987; 9 (4) 422-425
- 107 Suzuki Y, Nagai T, Ono J , et al. Zonisamide monotherapy in newly diagnosed infantile spasms. Epilepsia 1997; 38 (9) 1035-1038
- 108 Yanai S, Hanai T, Narazaki O. Treatment of infantile spasms with zonisamide. Brain Dev 1999; 21 (3) 157-161
- 109 Lotze TE, Wilfong AA. Zonisamide treatment for symptomatic infantile spasms. Neurology 2004; 62 (2) 296-298
- 110 Yanagaki S, Oguni H, Yoshii K , et al. Zonisamide for West syndrome: a comparison of clinical responses among different titration rate. Brain Dev 2005; 27 (4) 286-290
- 111 Yum MS, Ko TS. Zonisamide in West syndrome: an open label study. Epileptic Disord 2009; 11 (4) 339-344
- 112 Gümüş H, Kumandaş S, Per H. Levetiracetam monotherapy in newly diagnosed cryptogenic West syndrome. Pediatr Neurol 2007; 37 (5) 350-353
- 113 Mikati MA, El Banna D, Sinno D, Mroueh S. Response of infantile spasms to levetiracetam. Neurology 2008; 70 (7) 574-575
- 114 Mahmoud AA, Rizk TM, Mansy AA, Ali JA, Al-Tannir MA. Ineffectiveness of topiramate and levetiracetam in infantile spasms non-responsive to steroids. Open labeled randomized prospective study. Neurosciences (Riyadh) 2013; 18 (2) 143-146
- 115 Glauser TA, Clark PO, Strawsburg R. A pilot study of topiramate in the treatment of infantile spasms. Epilepsia 1998; 39 (12) 1324-1328
- 116 Hosain SA, Merchant S, Solomon GE, Chutorian A. Topiramate for the treatment of infantile spasms. J Child Neurol 2006; 21 (1) 17-19
- 117 Zou LP, Ding CH, Fang F, Sin NC, Mix E. Prospective study of first-choice topiramate therapy in newly diagnosed infantile spasms. Clin Neuropharmacol 2006; 29 (6) 343-349
- 118 Zou LP, Lin Q, Qin J, Cai FC, Liu ZS, Mix E ; Topiramate Study Group. Evaluation of open-label topiramate as primary or adjunctive therapy in infantile spasms. Clin Neuropharmacol 2008; 31 (2) 86-92
- 119 Watemberg N, Goldberg-Stern H, Ben-Zeev B , et al. Clinical experience with open-label topiramate use in infants younger than 2 years of age. J Child Neurol 2003; 18 (4) 258-262
- 120 Grosso S, Franzoni E, Iannetti P , et al. Efficacy and safety of topiramate in refractory epilepsy of childhood: long-term follow-up study. J Child Neurol 2005; 20 (11) 893-897
- 121 Valencia I, Fons C, Kothare SV , et al. Efficacy and tolerability of topiramate in children younger than 2 years old. J Child Neurol 2005; 20 (8) 667-669
- 122 Korinthenberg R, Schreiner A. Topiramate in children with west syndrome: a retrospective multicenter evaluation of 100 patients. J Child Neurol 2007; 22 (3) 302-306
- 123 Al-Baradie RS, Elseed MA. West syndrome, can topiramate be on top?. Neurosciences (Riyadh) 2011; 16 (1) 53-56
- 124 Izuora GI, Iloeje SO. Pyridoxine therapy on Nigerian children with infantile spasms. East Afr Med J 1989; 66 (8) 525-530
- 125 Ito M, Okuno T, Hattori H, Fujii T, Mikawa H. Vitamin B6 and valproic acid in treatment of infantile spasms. Pediatr Neurol 1991; 7 (2) 91-96
- 126 Pietz J, Benninger C, Schäfer H, Sontheimer D, Mittermaier G, Rating D. Treatment of infantile spasms with high-dosage vitamin B6. Epilepsia 1993; 34 (4) 757-763
- 127 Gaily E, Appelqvist K, Kantola-Sorsa E , et al. Cognitive deficits after cryptogenic infantile spasms with benign seizure evolution. Dev Med Child Neurol 1999; 41 (10) 660-664
- 128 Ohtsuka Y, Ogino T, Asano T, Hattori J, Ohta H, Oka E. Long-term follow-up of vitamin B(6)-responsive West syndrome. Pediatr Neurol 2000; 23 (3) 202-206
- 129 Pavone L, Incorpora G, La Rosa M, Li Volti S, Mollica F. Treatment of infantile spasms with sodium dipropylacetic acid. Dev Med Child Neurol 1981; 23 (4) 454-461
- 130 Bachman DS. Use of valproic acid in treatment of infantile spasms. Arch Neurol 1982; 39 (1) 49-52
- 131 Dyken PR, DuRant RH, Minden DB, King DW. Short term effects of valproate on infantile spasms. Pediatr Neurol 1985; 1 (1) 34-37
- 132 Siemes H, Spohr HL, Michael T, Nau H. Therapy of infantile spasms with valproate: results of a prospective study. Epilepsia 1988; 29 (5) 553-560
- 133 Auvichayapat N, Tassniyom S, Treerotphon S, Auvichayapat P. Treatment of infantile spasms with sodium valproate followed by benzodiazepines. J Med Assoc Thai 2007; 90 (9) 1809-1814
- 134 Hong AM, Turner Z, Hamdy RF, Kossoff EH. Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infants. Epilepsia 2010; 51 (8) 1403-1407
- 135 Pires ME, Ilea A, Bourel E , et al. Ketogenic diet for infantile spasms refractory to first-line treatments: an open prospective study. Epilepsy Res 2013; 105 (1–2) 189-194
- 136 Kayyali HR, Gustafson M, Myers T, Thompson L, Williams M, Abdelmoity A. Ketogenic diet efficacy in the treatment of intractable epileptic spasms. Pediatr Neurol 2014; 50 (3) 224-227
- 137 Nordli Jr DR, Kuroda MM, Carroll J , et al. Experience with the ketogenic diet in infants. Pediatrics 2001; 108 (1) 129-133
- 138 Kossoff EH, Pyzik PL, McGrogan JR, Vining EP, Freeman JM. Efficacy of the ketogenic diet for infantile spasms. Pediatrics 2002; 109 (5) 780-783
- 139 François LL, Manel V, Rousselle C, David M. [Ketogenic regime as anti-epileptic treatment: its use in 29 epileptic children]. Arch Pediatr 2003; 10 (4) 300-306
- 140 Eun SH, Kang HC, Kim DW, Kim HD. Ketogenic diet for treatment of infantile spasms. Brain Dev 2006; 28 (9) 566-571
- 141 Kang HC, Lee YM, Kim HD, Lee JS, Slama A. Safe and effective use of the ketogenic diet in children with epilepsy and mitochondrial respiratory chain complex defects. Epilepsia 2007; 48 (1) 82-88
- 142 Numis AL, Yellen MB, Chu-Shore CJ, Pfeifer HH, Thiele EA. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Res 2011; 96 (1–2) 172-175
- 143 Lee J, Lee JH, Yu HJ, Lee M. Prognostic factors of infantile spasms: role of treatment options including a ketogenic diet. Brain Dev 2013; 35 (8) 821-826
- 144 Hirano Y, Oguni H, Shiota M, Nishikawa A, Osawa M. Ketogenic diet therapy can improve ACTH-resistant West syndrome in Japan. Brain Dev 2015; 37 (1) 18-22
- 145 Palm DG, Brandt M, Korinthenberg R. West- and Lennox–Gastaut syndromes and other epilepsies with porencephalic cysts. In: Niedermeyer E, Degen R, eds. The Lennox–Gastaut syndrome. New York, NY: Alan R. Liss, Inc.; 1988: 419-426
- 146 Carrazana EJ, Lombroso CT, Mikati M, Helmers S, Holmes GL. Facilitation of infantile spasms by partial seizures. Epilepsia 1993; 34 (1) 97-109
- 147 Chugani HT, Shewmon DA, Shields WD , et al. Surgery for intractable infantile spasms: neuroimaging perspectives. Epilepsia 1993; 34 (4) 764-771
- 148 Asarnow RF, LoPresti C, Guthrie D , et al. Developmental outcomes in children receiving resection surgery for medically intractable infantile spasms. Dev Med Child Neurol 1997; 39 (7) 430-440
- 149 Kramer U, Sue WC, Mikati MA. Focal features in West syndrome indicating candidacy for surgery. Pediatr Neurol 1997; 16 (3) 213-217
- 150 Pinard JM, Delalande O, Chiron C , et al. Callosotomy for epilepsy after West syndrome. Epilepsia 1999; 40 (12) 1727-1734
- 151 Jonas R, Asarnow RF, LoPresti C , et al. Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms. Neurology 2005; 64 (4) 746-750
- 152 Kang HC, Hwang YS, Park JC , et al. Clinical and electroencephalographic features of infantile spasms associated with malformations of cortical development. Pediatr Neurosurg 2006; 42 (1) 20-27
- 153 Loddenkemper T, Holland KD, Stanford LD, Kotagal P, Bingaman W, Wyllie E. Developmental outcome after epilepsy surgery in infancy. Pediatrics 2007; 119 (5) 930-935
- 154 Iwatani Y, Kagitani-Shimono K, Tominaga K , et al. Long-term developmental outcome in patients with West syndrome after epilepsy surgery. Brain Dev 2012; 34 (9) 731-738
- 155 Chellamuthu P, Sharma S, Jain P, Kaushik JS, Seth A, Aneja S. High dose (4 mg/kg/day) versus usual dose (2 mg/kg/day) oral prednisolone for treatment of infantile spasms: an open-label, randomized controlled trial. Epilepsy Res 2014; 108 (8) 1378-1384
- 156 Weber A, Cole JW, Mytinger JR. Infantile Spasms Respond Poorly to Topiramate. Pediatr Neurol 2015; 53 (2) 130-134
- 157 Djuric M, Kravljanac R, Tadic B, Mrlješ-Popovic N, Appleton RE. Long-term outcome in children with infantile spasms treated with vigabatrin: a cohort of 180 patients. Epilepsia 2014; 55 (12) 1918-1925
- 158 Jones K, Go C, Boyd J , et al. Vigabatrin as first-line treatment for infantile spasms not related to tuberous sclerosis complex. Pediatr Neurol 2015; 53 (2) 141-145
- 159 Lee YJ, Lee JS, Kang HC , et al. Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy. Brain Dev 2014; 36 (6) 496-504
- 160 O'Callaghan FJK, Edwards S, Hancock E , et al. OP50–3017: The International Collaborative Infantile Spasms Study (ICISS) comparing hormonal therapies (prednisolone or tetracosactide depot) and vigabatrin versus hormonal therapies alone in the treatment of infantile spasms: Early clinical outcome. Eur J Paediatr Neurol 2015; 19 (Suppl. 01) S16-S17