Cell Manipulation in Pediatric Haploidentical Stem Cell Transplantation: State of the Art

Manuela Tumino; Antonio Marzollo; Maria Vittoria Gazzola; Elisabetta Calore; Chiara Mainardi; Marta Pillon; Roberta Destro; Maria Gabelli; Aurora Strano; Matteo Barioni; Chiara Messina

doi:10.1055/s-0036-1572322

Journal of Pediatric Biochemistry, Table of Contents

Journal of Pediatric Biochemistry 2015; 05(04): 115-119
DOI: 10.1055/s-0036-1572322

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Cell Manipulation in Pediatric Haploidentical Stem Cell Transplantation: State of the Art

Manuela Tumino

¹Pediatric Hematology and Oncology Division, Department of Woman's and Child's Health, University of Padova, Padova PD, Italy

,

Antonio Marzollo

¹Pediatric Hematology and Oncology Division, Department of Woman's and Child's Health, University of Padova, Padova PD, Italy

,

Maria Vittoria Gazzola

²Stem Cell Transplantation Laboratory, University of Padova, Padova PD, Italy

,

Elisabetta Calore

¹Pediatric Hematology and Oncology Division, Department of Woman's and Child's Health, University of Padova, Padova PD, Italy

,

Chiara Mainardi

¹Pediatric Hematology and Oncology Division, Department of Woman's and Child's Health, University of Padova, Padova PD, Italy

,

Marta Pillon

¹Pediatric Hematology and Oncology Division, Department of Woman's and Child's Health, University of Padova, Padova PD, Italy

,

Roberta Destro

²Stem Cell Transplantation Laboratory, University of Padova, Padova PD, Italy

,

Maria Gabelli

¹Pediatric Hematology and Oncology Division, Department of Woman's and Child's Health, University of Padova, Padova PD, Italy

,

Aurora Strano

²Stem Cell Transplantation Laboratory, University of Padova, Padova PD, Italy

,

Matteo Barioni

²Stem Cell Transplantation Laboratory, University of Padova, Padova PD, Italy

,

Chiara Messina

¹Pediatric Hematology and Oncology Division, Department of Woman's and Child's Health, University of Padova, Padova PD, Italy

› Author Affiliations

Abstract

Haploidentical transplantation in children can extend the opportunity for transplantation to almost every patient lacking a human leukocyte antigen (HLA)–matched donor and offer this treatment to every child with an otherwise incurable disease. Although initial attempts were associated with a high transplant-related mortality, recent insights into the biology of haploidentical transplantation, the availability of effective ex vivo large-scale graft-manipulation technology, and improved supportive care strategies have led to significantly better outcomes. Concurrently, the indication for haploidentical transplantation has been extended, including different malignant and nonmalignant conditions. Worldwide donor registries include mainly donors of Caucasian origin. Patients of non-Caucasian origin have a lower chance of finding a suitable unrelated donor. Haploidentical transplantation allows the treatment of children independently of their ethnic background in a timely fashion. One of the major advantages of using a related donor is the possibility of collecting or generating additional cellular products from the same donor to open the possibility of enhancing both the antitumor effects of the graft and the immunologic reconstitution after transplantation.

Keywords

haploidentical transplantation - graft manipulation - pediatric diseases

Full Text

References

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