J Neurol Surg Rep 2016; 77(01): e62-e65
DOI: 10.1055/s-0035-1571204
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Regression of Intracranial Meningioma during Treatment with α1-Adrenoceptor Blocker

Einar August Hoegestoel
1  Department of Neurosurgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
,
Jon Berg-Johnsen
1  Department of Neurosurgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
2  Faculty of Medicine, University of Oslo, Oslo, Norway
› Author Affiliations
Further Information

Publication History

31 August 2015

03 December 2015

Publication Date:
11 May 2016 (online)

Abstract

Background Regression of meningioma has been reported after hemorrhage or hormonal withdrawal. Here, we report a case of an incidentally diagnosed meningioma that regressed in association with α1-adrenoceptor antagonist.

Case report A 59-year old male patient with an incidentally diagnosed lateral sphenoid wing meningioma was followed with serial magnetic resonance imaging. The tumor with a maximum diameter of 43 mm showed progressive regression, and after 3 years the size was reduced to 22% of the initial volume. During follow-up the patient was treated with an α1-adrenoceptor antagonist (tamsulosin) for benign prostatic hyperplasia. Possible mechanisms are discussed, including our main hypothesis of reduced mitogenic effects through phospholipase C-signal transduction.

Conclusion This is the first report of regression of an incidentally diagnosed meningioma associated with α1-adrenoceptor antagonist treatment.

Note

An abstract of this case history was presented at the Annual Meeting of the Norwegian Neurosurgical Society; October 26, 2014; Norway.