Semin Thromb Hemost 2016; 42(03): 242-251
DOI: 10.1055/s-0035-1570079
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Role of Platelets in Venous Thromboembolism

Silvia Montoro-García
1  Department of Cardiovascular Risk, Faculty of Health Sciences, UCAM Universidad Católica San Antonio de Murcia, Campus de los Jerónimos, Guadalupe, Murcia, Spain
,
Marc Schindewolf
2  Division of Vascular Medicine, University Hospital Bern, Swiss Cardiovascular Center, Bern, Switzerland
,
Sophia Stanford
3  Department of Haemophilia, Haemostasis and Thrombosis, North Hampshire NHS Trust, Basingstoke, Hampshire, United Kingdom
,
Ole Halfdan Larsen
4  Department of Clinical Biochemistry, Aarhus University Hospital, Centre for Hemophilia and Thrombosis, Aarhus, Denmark
,
Thomas Thiele
5  Institute for Immunology and Transfusion Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
29 February 2016 (online)

Abstract

Multiple factors contribute to the risk of venous thromboembolism (VTE). Platelets have attracted much interest in arterial cardiovascular disease, whereas their role in VTE has received much less attention. Recent evidence suggests that platelets may play a more important role in VTE than previously anticipated. This review discusses the mechanisms that link platelets with venous thrombotic disease and their potential applications as novel risk factors for VTE. In addition, animal studies and randomized clinical trials that highlight the potential effect of antiplatelet therapy in venous thrombosis are evaluated to assess the role of platelets in VTE. The clinical significance of platelets for VTE risk assessment in specific patient cohorts and their role as a suitable therapeutic target for VTE prevention is acknowledged. The role of platelets in VTE is a promising field for future research.

Notes on Contributors

All authors contributed equally as members of the writing group.