Journal of Pediatric Epilepsy 2016; 05(02): 111-114
DOI: 10.1055/s-0035-1570021
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Seizures Are Not a Prevalent Feature of Wyburn-Mason Syndrome

Renata Rizzo
1   Section of Child Neuropsychiatry, Department of Medical and Pediatric Sciences, University of Catania, Catania, Italy
Piero Pavone
2   Department of Pediatrics and Pediatric Emergency Costanza Gravina, University Hospital, Vittorio Emanuele-Policlinico, Catania, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
21 December 2015 (online)


Wyburn-Mason syndrome (WMS) is a widely recognized neurocutaneous syndrome in which the unilateral anterior venous malformation in its complete form is associated with eye, brain, and skin involvement. The term WMS also includes the incomplete form in which the patients show unilateral anterior venous malformation as a single anomaly not associated with other districts involvement. Neurologic complications are almost constantly reported in this syndrome. The aim of this report is to describe the neurologic course of two patients affected by the complete form of this very rare syndrome offering particular remarks whether convulsive episodes or epilepsy are leading features of this disorder. Based on the experience registered in the long follow-up in the present patients and in those reported in the literature, seizures and convulsive episodes are uncommon in WMS and, when present, mainly occur in consequence of acute or chronic disruptive events of the arteriovenous malformations.