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Planta Med 2016; 82(07): 645-649
DOI: 10.1055/s-0035-1568276
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

New Alkyl Phloroglucinol Derivatives from Rhus trichocarpa Roots and Their Cytotoxic Effects on Human Gastric Adenocarcinoma AGS Cells

Ki Yong Lee
1   College of Pharmacy, Korea University, Sejong, Republic of Korea
2   College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea
,
Ji Hoon Choi
2   College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea
,
Hyeon Woo Kim
2   College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea
,
Xi-Tao Yan
1   College of Pharmacy, Korea University, Sejong, Republic of Korea
,
Hyeji Shin
1   College of Pharmacy, Korea University, Sejong, Republic of Korea
,
Young Ho Jeon
1   College of Pharmacy, Korea University, Sejong, Republic of Korea
,
Sang Hyun Sung
2   College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea
› Author Affiliations
Further Information

Publication History

received 16 October 2015
revised 25 November 2015

accepted 14 December 2015

Publication Date:
04 February 2016 (online)

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Abstract

The phytochemical investigation of the roots of Rhus trichocarpa led to this isolation of five new alkyl phloroglucinol derivatives, characterized as (Z)-15-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol A, 1), (Z)-15-hydroxy-1-(2,6-dihydroxy-4-methoxyphenyl)-9-octadecen-1-one (named trichocarpol B, 2), (Z)-17-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol C, 3), (Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol D, 4), and (9Z,12Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9,12-octadecadien-1-one (named trichocarpol E, 5), together with a known compound, 4-(2,6-dihydroxy-4-methoxyphenyl)-4-oxobutanoic acid (6). In vitro cytotoxic activity of compounds 1–6 was evaluated in the human gastric adenocarcinoma AGS cell line and compounds 1–5 showed significant cytotoxicity. Our results indicate that R. trichocarpa, especially the alkyl phloroglucinol derivatives in it, is a good source of promising natural agents for the treatment of gastric cancer.

Key words

Rhus trichocarpa - Anacardiaceae - alkyl phloroglucinols - cytotoxicity - AGS cells

Supporting Information

 

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