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Semin Liver Dis 2015; 35(04): 434-438
DOI: 10.1055/s-0035-1567828
Diagnostic Problems in Hepatology
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Beneath the Copper—Pediatric Wilson's Disease Cirrhosis and Hepatocellular Carcinoma: A Case Report with Literature Review

Richard A. Rosencrantz
1   Department of Pediatrics, Section of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York
2   Center for Transplantation, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York
,
Lesli LeCompte
3   Department of Radiology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York
,
Yasmin Yusuf
4   Department of Pathology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York
› Author Affiliations
Further Information

Publication History

Publication Date:
16 December 2015 (online)

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Abstract

Primary hepatic malignancies are uncommon in pediatrics. Tumors such as hepatocellular carcinoma (HCC) develop typically in the setting of chronic liver disease. The incidence of HCC in Wilson's disease-related cirrhosis is disproportionately lower than in many other forms of end-stage liver disease. A preadolescent girl presented with Wilson's disease cirrhosis and a HCC requiring orthotopic liver transplantation. This case highlights the need to consider hepatic malignancies even in young Wilson's disease patients. Pediatric Wilson's disease and the hepatic tumor literature are reviewed.

Keywords

Wilson's disease - hepatocellular carcinoma - pediatrics - liver transplantation
 

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