J Neurol Surg A Cent Eur Neurosurg 2015; 76 - A058
DOI: 10.1055/s-0035-1566377

Frame-Based CT-Guided Stereotactic Biopsy in Treatment of Different Brain Lesions

Bojan Jelača 1, Petar Vuleković 1, Vladimir Papić 1, Mladen Karan 1, Tomislav Cigić 1, Đula Đilvesi 1, Jagoš Golubović 1
  • 1Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia

Introduction Frame-based stereotactic brain biopsy is a way of acquiring histological diagnosis and is an important step in decision-making process in treatment of patients with different brain lesions.

Aim This study presents analysis of clinical, radiological, and histological data to evaluate the reliability, accuracy, and efficacy of the stereotactic brain biopsy.

Material and Methods This retrospective study included a total of 108 patients who were hospitalized because of the intracranial lesions at the Department of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia, from January 2009 to December 2014. Age ranged from 16 to 81 years with a mean age of 61.15 years. All patients underwent CT-guided stereotactic brain biopsy in the general anesthesia.

Results Most frequent by location were deep-seated lesions (thalamus/basal ganglia) in 58%. Multiple lesions were represented in 23%. In the whole group, we performed frozen section histological examination during the stereotactic procedure and later histological and immunohistochemical analysis. Of the tumoral lesions, 83 (77.6%) were primary central nervous system tumors, 15 (14%) were metastatic, and 9 (8.4%) were primary CNS lymphoma. We achieved almost 100% diagnostic value in histopathology analysis with an average of nine sample bits per single biopsy. There was only one transient and one permanent neurological deficit after the procedure. Patients were discharged from our clinic usually on the fourth or fifth postoperative day.

Conclusion Through past decades, frame-based stereotactic biopsy is established as a safe and reliable procedure, with minimum or without any complications, in the diagnosis and further therapy management of brain lesions.

Keywords frame-based stereotactic brain biopsy; brain tumor; reliability and accuracy; histological diagnosis