European J Pediatr Surg Rep. 2015; 03(02): 090-093
DOI: 10.1055/s-0035-1566219
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Preoperative Interventional Therapy for Childhood Undifferentiated Embryonal Liver Sarcoma: Two Retrospective Cases from a Single Center

Xiaoxia Zhao
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
,
Qixing Xiong
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
,
Jinhu Wang
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
,
Min-Ju Li
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
,
Qi Qin
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
,
Shoujiang Huang
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
,
Weizhong Gu
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
,
Qiang Shu
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
,
Jinfa Tou
1  Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
› Author Affiliations
Further Information

Publication History

29 November 2014

17 September 2015

Publication Date:
19 November 2015 (online)

Abstract

Background Undifferentiated embryonal liver sarcoma (UELS) accounts for only 9 to 15% of all malignant liver tumors in children. Typically, UELS occurs in older children and presents as an abdominal mass. Most UELS are unresectable because of the later diagnosis. The outcome of UELS is very poor, with a 5-year overall survival of < 37.5%. Transarterial chemoembolization (TACE) has been reported to be an effective modality for unresectable liver tumors. To investigate the effects of TACE on UELS in children, we present two cases of children with UELS who underwent TACE and surgical resection in our center within the past 10 years.

Methods In this study, two children with UELS were treated using TACE with cisplatin, doxorubicin, and iodized oil. The size of the tumors was measured before and after TACE using ultrasonography. Routine was also given before and after surgical resection. Side effects were recorded. Both patients had follow-up.

Results After interventional therapy, both patients presented with vomiting, fever, and transient liver dysfunction without cardiac or renal dysfunction. One patient had bone marrow depression. The size of the tumors was reduced by 23% to 31% after TACE. The tumors were completely removed by surgical procedures after 4 weeks of TACE in both patients. One patient survived free of disease for 1 year, and the other survived free of disease for 9 years.

Conclusion TACE yielded satisfactory results for unresectable UELS in children, with lower dosage of chemotherapy and fewer side effects. It may be applied as a preoperative therapy for children with unresectable UELS.