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DOI: 10.1055/s-0035-1565413
Chemical constituents and their bioactivities from the stem of Neolitsea konishii
Neolitsea konishii (Hay.) Kanehira & Sasaki (Lauraceae) is a small evergreen tree that is distributed in the Ryukyus and Taiwan. The methanolic extract of the stem of Neolitsea konishii has been shown with anti-eβG (Escherichia coli β glucuronidase) and anti-inflammatory activities. The anti-eβG activity of the stem of N. konishii has not yet been investigated; therefore, the aim of this study is to isolate its chemical constituents and evaluate their biological activities.
Bioassay-guided fractionation of the stem of N. konishii has led to the isolation of one new 1,3-diphenylbutanoid, (-)-konishibutanin and two new lignans, neokoninins A and B, along with 21 known compounds till now. The structures of these isolates were elucidated by spectral methods. Among the isolates, 132-hydroxy-(l32-R)-pheophytin a and N-trans-feruloyl-3',4'-dihydroxyphenylethylamine exhibited potent anti-eβG activity with inhibition ratio of 88% and 76% and with low inhibition of hβG (human β glucuronidase) respectively. In addition, trans-9,9'-O-di-(E)-feruloyl-(-)-secoisolariciresinol showed potent inhibitory U46619 factor and fMLP-induced superoxide generation in human neutrophils activity with IC50 values of 7.89 ± 0.35 and 2.43 ± 0.03 µM.