Planta Med 2015; 81 - SL4A_03
DOI: 10.1055/s-0035-1565333

Gastroprotective activity of the rhizome ethanol extract of Zingiber simaoense Y. Y. Qian in rats

P Baiubol 1, P Kunanusorn 1, P Khonsung 1, N Chiranthanut 1, A Panthong 1, C Rujjanawate 2
  • 1Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
  • 2School of Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand

Zingiber simaoense Y. Y. Qian belongs to Zingiberaceae family [1,2]. Its rhizome is used in Thai traditional medicine to treat gastric disorders. Since the scientific evidences for its pharmacological activities have not yet been reported, the present study aimed to investigate the gastroprotective activity of its rhizome ethanol extract in rats. The gastric ulcer models induced by ethanol/hydrochloric acid [3], indomethacin [4], and restraint water immersion stress [5] were used to test its activity. After oral administration, the extract at the doses of 7.5, 15, and 30 mg/kg as well as cimetidine (100 mg/kg) significantly inhibited gastric ulcer formation in all models. These findings indicate that the rhizome ethanol extract of Zingiber simaoense possesses gastroprotective activity which may relate to the cytoprotective activity and the inhibition of gastric acid secretion.

Acknowledgement: This work was supported by the Center for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education and the Faculty of Medicine Research Fund, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

References:

[1] Qian YY. Zingiber simaoense Y.Y. Qian Bull Bot Res, Harbin 1998;18: 284 – 286.

[2] Flora of China Editorial Committee. Flora of China (Flagellariaceae through Marantaceae). In: Wu CY, Raven PH, Hong DY, editors. Flora of China. Science Press, Beijing and Missouri Botanical Garden Press, St. Louis; 2000;24:1 – 431.

[3] Mizui T, Doteuchi M. Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Jpn J Pharmacol 1988; 33: 939 – 945.

[4] Nwafor P, Okwuasaba F, Binda L. Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. J Ethnopharmacol 2000; 72: 421 – 427.

[5] Takagi K, Kasuya Y, Watanabe K. Studies on the drug for peptic ulcer. A reliable method for producing stress ulcer in rats. Chem Pharm Bull 1964; 12: 465 – 472.