J Neurol Surg Rep 2015; 76(02): e258-e264
DOI: 10.1055/s-0035-1564601
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Chondroblastoma of the Clivus: Case Report and Review

Jonathan Liu
1   Department of Neurological Surgery, UC Davis School of Medicine, Sacramento, California, United States
,
Arjang Ahmadpour
1   Department of Neurological Surgery, UC Davis School of Medicine, Sacramento, California, United States
,
Arnaud F. Bewley
2   Department of Otolaryngology, UC Davis School of Medicine, Sacramento, California, United States
,
Mirna Lechpammer
3   Department of Pathology, UC Davis School of Medicine, Sacramento, California, United States
,
Matthew Bobinski
4   Department of Radiology, UC Davis School of Medicine, Sacramento, California, United States
,
Kiarash Shahlaie
1   Department of Neurological Surgery, UC Davis School of Medicine, Sacramento, California, United States
› Author Affiliations
Further Information

Publication History

20 January 2015

10 August 2015

Publication Date:
09 October 2015 (online)

Abstract

Background and Importance Chondroblastoma is a benign primary bone tumor that typically develops in the epiphyses of long bones. Chondroblastoma of the craniofacial skeleton is extremely rare, with most cases occurring in the squamosal portion of the temporal bone. In this report, we describe the first case of chondroblastoma of the clivus presenting with cranial neuropathy that was treated with endoscopic endonasal resection. We review the literature on craniofacial chondroblastomas with particular emphasis on extratemporal lesions.

Case Presentation A 27-year-old woman presented with severe headache, left facial dysesthesias, and diplopia. Physical examination revealed hypesthesia in the left maxillary nerve dermatome, and complete left abducens nerve palsy. Imaging demonstrated an expansile intraosseous mass originating in the upper clivus with extension superiorly into the sella turcica and laterally to involve the medial wall of the left cavernous sinus. The tumor was completely resected via an endoscopic endonasal approach, with postoperative improvement in lateral gaze palsy. Histopathology was consistent with chondroblastoma.

Conclusion Chondroblastoma is a rare tumor of the craniofacial skeleton that should be included in the differential diagnosis of an osteolytic lesion of the clivus. Complete surgical resection remains the mainstay of treatment.

 
  • References

  • 1 Dahlin DC, Ivins JC. Benign chondroblastoma. A study of 125 cases. Cancer 1972; 30 (2) 401-413
  • 2 Kurt AM, Unni KK, Sim FH, McLeod RA. Chondroblastoma of bone. Hum Pathol 1989; 20 (10) 965-976
  • 3 Jaffe HL, Lichtenstein L. Benign Chondroblastoma of Bone: A Reinterpretation of the So-Called Calcifying or Chondromatous Giant Cell Tumor. Am J Pathol 1942; 18 (6) 969-991
  • 4 Hong SM, Park YK, Ro JY. Chondroblastoma of the temporal bone: a clinicopathologic study of five cases. J Korean Med Sci 1999; 14 (5) 559-564
  • 5 Flowers CH, Rodriguez J, Naseem M, Reyes MM, Verano AS. MR of benign chondroblastoma of the temporal bone. AJNR Am J Neuroradiol 1995; 16 (2) 414-416
  • 6 Al-Dewachi HS, Al-Naib N, Sangal BC. Benign chondroblastoma of the maxilla: a case report and review of chondroblastomas in cranial bones. Br J Oral Surg 1980; 18 (2) 150-156
  • 7 Dran G, Niesar E, Vandenbos F, Noel G, Paquis P, Lonjon M. Chondroblastoma of the apex portion of petrousal bone. Childs Nerv Syst 2007; 23 (2) 231-235
  • 8 Horn KL, Hankinson H, Nagel B, Erasmus M. Surgical management of chondroblastoma of the temporal bone. Otolaryngol Head Neck Surg 1990; 102 (3) 264-269
  • 9 Bertoni F, Unni KK, Beabout JW, Harner SG, Dahlin DC. Chondroblastoma of the skull and facial bones. Am J Clin Pathol 1987; 88 (1) 1-9
  • 10 Hatano M, De Donato G, Falcioni M, Sanna M. Chondroblastoma of the temporal bone. Acta Otolaryngol 2011; 131 (8) 890-895
  • 11 Kutz Jr JW, Verma S, Tan HT, Lo WW, Slattery III WH, Friedman RA. Surgical management of skull base chondroblastoma. Laryngoscope 2007; 117 (5) 848-853
  • 12 Reid LB, Wong DS, Lyons B. Chondroblastoma of the temporal bone: a case series, review, and suggested management strategy. Skull Base Rep 2011; 1 (2) 71-82
  • 13 Blaauw G, Prick JJ, Versteege C. Chondroblastoma of the temporal bone. Neurosurgery 1988; 22 (6 Pt 1) 1102-1107
  • 14 Feely M, Keohane C. Chondroblastoma of the skull. J Neurol Neurosurg Psychiatry 1984; 47 (12) 1348-1350
  • 15 Shek TW. Chondroblastoma of temporal bone. Am J Otol 2000; 21 (4) 597-598
  • 16 Tanohata K, Noda M, Katoh H , et al. Chondroblastoma of temporal bone. Neuroradiology 1986; 28 (4) 367-370
  • 17 Watanabe N, Yoshida K, Shigemi H, Kurono Y, Mogi G. Temporal bone chondroblastoma. Otolaryngol Head Neck Surg 1999; 121 (3) 327-330
  • 18 Bian LG, Sun QF, Zhao WG, Shen JK, Tirakotai W, Bertalanffy H. Temporal bone chondroblastoma: a review. Neuropathology 2005; 25 (2) 159-164
  • 19 Shono T, Mizoguchi M, Yoshimoto K, Amano T, Natori Y, Sasaki T. Clinical course of abducens nerve palsy associated with skull base tumours. Acta Neurochir (Wien) 2009; 151 (7) 733-738 , discussion 738
  • 20 Burgin SJ, Porter RG, Mehrota S, Welch KC. Chondroblastoma of the sphenoid sinus. . Otolaryngol Head Neck Surg 2010; 143 (4) 591-592
  • 21 Cabrera RA, Almeida M, Mendonça ME, Frable WJ. Diagnostic pitfalls in fine-needle aspiration cytology of temporomandibular chondroblastoma: report of two cases. Diagn Cytopathol 2006; 34 (6) 424-429
  • 22 Kondoh T, Hamada Y, Kamei K, Seto K. Chondroblastoma of the mandibular condyle: report of a case. J Oral Maxillofac Surg 2002; 60 (2) 198-203
  • 23 Lee KF, Whiteley III WH, Schatz NJ, Edeiken J, Lin SR, Tsai FY. Juxtasellar hyperostosis of non-meningiomatous origin. J Neurosurg 1976; 44 (5) 571-579
  • 24 Martinez-Madrigal F, Vanel D, Luboinski B, Terrier P. Case report 670: Chondroblastoma maxillary sinus. Skeletal Radiol 1991; 20 (4) 299-301
  • 25 Ohnishi T, Oku Y, Yamamoto K, Morimura Y, Ushio Y. Benign chondroblastoma of the occipital bone. Surg Neurol 1985; 24 (1) 52-56
  • 26 Badia DM, Vallogini P, Marinelli M, Agrestini C. Benign chondroblastoma localized in the maxilla [in Italian]. Stomatol Mediterr 1985; 5 (1) 75-80
  • 27 Araújo JF, De Castro GC, Iafigliola MG, Balbo RJ. Benign chondroblastoma of the occipital bone. A case report [in Portuguese]. Arq Neuropsiquiatr 1995; 53 (4) 834-836
  • 28 Goodsell JO, Hubinger HL. Benign Chondroblastoma of Mandibular Condyle: Report of Case. J Oral Surg Anesth Hosp Dent Serv 1964; 22: 355-363
  • 29 Milazzo F. On an unusual case of chondroblastoma of the mandible [in Italian]. Arch Ital Otol Rinol Laringol 1967; 78 (1) 61-72
  • 30 Payne M, Yusuf H. Benign chondroblastoma involving the mandibular condyle. Br J Oral Maxillofac Surg 1987; 25 (3) 250-255
  • 31 al-Sader MH, Tait R, Leader M. Chondroblastoma—an unusual site in a young patient. J Laryngol Otol 1996; 110 (7) 696-699
  • 32 Miyake H, Hashi K, Nin K , et al. Intracranial benign chondroblastoma. A case report and review of the literature [in Japanese]. No Shinkei Geka 1984; 12 (3, Suppl): 419-425
  • 33 Harner SG, Cody DT, Dahlin DC. Benign chondroblastoma of the temporal bone. Otolaryngol Head Neck Surg (1979) 1979; 87 (2) 229-236
  • 34 Varvares MA, Cheney ML, Goodman ML, Ceisler E, Montgomery WW. Chondroblastoma of the temporal bone. Case report and literature review. Ann Otol Rhinol Laryngol 1992; 101 (9) 763-769
  • 35 Selesnick SH, Levine JM. Chondroblastoma of the temporal bone: consistent middle fossa involvement. Skull Base Surg 1999; 9 (4) 301-305
  • 36 Chavan SS, Yenni V, Kulkarni M. Chondroblastoma of squamous part of the temporo-parietal region of skull vault: a case report and review of literature. N Am J Med Sci 2012; 4 (4) 199-202
  • 37 Krishan K, Kanchan T. Evaluation of spheno-occipital synchondrosis: A review of literature and considerations from forensic anthropologic point of view. J Forensic Dent Sci 2013; 5 (2) 72-76
  • 38 Granados R, Martín-Hita A, Rodríguez-Barbero JM, Murillo N. Fine-needle aspiration cytology of chondroblastoma of soft parts: case report and differential diagnosis with other soft tissue tumors. Diagn Cytopathol 2003; 28 (2) 76-81
  • 39 Fanning CV, Sneige NS, Carrasco CH, Ayala AG, Murray JA, Raymond AK. Fine needle aspiration cytology of chondroblastoma of bone. Cancer 1990; 65 (8) 1847-1863
  • 40 Ishikawa E, Tsuboi K, Onizawa K , et al. Chondroblastoma of the temporal base with high mitotic activity. Neurol Med Chir (Tokyo) 2002; 42 (11) 516-520
  • 41 Pontius A, Reder P, Ducic Y. Temporal bone chondroblastomas. Am J Otolaryngol 2003; 24 (6) 370-373
  • 42 Bloem JL, Mulder JD. Chondroblastoma: a clinical and radiological study of 104 cases. Skeletal Radiol 1985; 14 (1) 1-9
  • 43 Muntané A, Valls C, Angeles de Miquel MA, Pons LC. Chondroblastoma of the temporal bone: CT and MR appearance. AJNR Am J Neuroradiol 1993; 14 (1) 70-71
  • 44 Leong HK, Chong PY, Sinniah R. Temporal bone chondroblastoma: big and small. J Laryngol Otol 1994; 108 (12) 1115-1119
  • 45 Stapleton CJ, Walcott BP, Linskey KR, Kahle KT, Nahed BV, Asaad WF. Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. J Clin Neurosci 2011; 18 (6) 857-860
  • 46 Moon IS, Kim J, Lee HK, Lee WS. Surgical treatment and outcomes of temporal bone chondroblastoma. Eur Arch Otorhinolaryngol 2008; 265 (12) 1447-1454
  • 47 Kurokawa R, Uchida K, Kawase T. Surgical treatment of temporal bone chondroblastoma. Surg Neurol 2005; 63 (3) 265-268 , discussion 268
  • 48 Lin PP, Thenappan A, Deavers MT, Lewis VO, Yasko AW. Treatment and prognosis of chondroblastoma. Clin Orthop Relat Res 2005; 438 (438) 103-109