Synthesis 2016; 48(20): 3567-3574
DOI: 10.1055/s-0035-1562777
paper
© Georg Thieme Verlag Stuttgart · New York

Catalytic Metal-Free Intramolecular Acylcyanation: Synthesis of Functionalized Pyridine Derivatives Bearing Pendent Stereocenters

Gong-Feng Zou
Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China   Email: wanghj@jlu.edu.cn   Email: wliao@jlu.edu.cn
,
Jia-Xin Wang
Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China   Email: wanghj@jlu.edu.cn   Email: wliao@jlu.edu.cn
,
Shi-Qiang Zhang
Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China   Email: wanghj@jlu.edu.cn   Email: wliao@jlu.edu.cn
,
Hai-Jing Wang*
Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China   Email: wanghj@jlu.edu.cn   Email: wliao@jlu.edu.cn
,
Wei-Wei Liao*
Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China   Email: wanghj@jlu.edu.cn   Email: wliao@jlu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 10 May 2016

Accepted after revision: 13 June 2016

Publication Date:
02 August 2016 (online)


Abstract

A novel protocol for the synthesis of functionalized pyridines containing quaternary carbon centers through a metal-free catalytic intramolecular acylcyanation approach has been developed. Broad scope, versatility, and efficiency of the process was demonstrated.

Supporting Information

 
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