Synthesis 2016; 48(20): 3544-3550
DOI: 10.1055/s-0035-1562440
paper
© Georg Thieme Verlag Stuttgart · New York

Regioselective Synthesis of 1,2-Benzothiazine 1,1-Dioxide Derivatives by Intramolecular Heck Cyclization

Sudarshan Debnath
b  Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India
,
Suniti Malakar
b  Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India
,
Shovan Mondal*
b  Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India
› Author Affiliations
Further Information

Publication History

Received: 27 March 2016

Accepted after revision: 10 May 2016

Publication Date:
24 June 2016 (online)


Abstract

An efficient method for the synthesis of bioactive heterocycles containing 1,2-benzothiazine 1,1-dioxide derivatives via Pd-catalyzed intramolecular Heck cyclization is reported. The method offers the regioselective synthesis of highly functionalized benzosultams in 80–85% yields. The structure of benzosultam derivatives is confirmed from single crystal X-ray diffraction.

Supporting Information

 
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