Synthesis 2016; 48(13): 1974-1992
DOI: 10.1055/s-0035-1561974
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Uses of Kröhnke Methodology: A Short Survey

I. Sasaki*
a  CNRS; LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, 31077 Toulouse, France
b  Université de Toulouse; UPS, INP, LCC, 31077 Toulouse, France   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 07 February 2016

Accepted after revision: 03 March 2016

Publication Date:
09 May 2016 (online)


Abstract

The scope of this short review is to point out how such an old reaction as the Kröhnke-type ring closure is still used nowadays to enable simple access to pyridines or polypyridines. Besides the usual Stille or Suzuki coupling reactions, which deal, respectively, with stannylated derivatives or boronic derivatives, the Kröhnke reaction can reach its target molecules with commercially available starting materials in a simple reaction medium without any special care.

1 Introduction

2 The Kröhnke Reaction

3 Applications

3.1 Catalysis

3.2 Materials

3.2.1 Dye-Sensitized Solar Cells

3.2.2 OLEDs and LECs

3.3 Biological Applications

3.3.1 Luminescent Probes

3.3.2 Chemosensors

3.3.3 Anticancer Compounds

3.3.4 Antimicrobial Activity

4 Miscellaneous

5 Summary and Outlook

 
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