Synlett 2016; 27(11): 1677-1681
DOI: 10.1055/s-0035-1561942
letter
© Georg Thieme Verlag Stuttgart · New York

Stereoselectivity in the Reduction of Bicyclic Tetramates

Laia Josa-Culleré, Mark G. Moloney*, Amber L. Thompson
  • Department of Chemistry, Chemistry Research Laboratory, The University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK   Email: mark.moloney@chem.ox.ac.uk
Further Information

Publication History

Received: 11 February 2016

Accepted: 28 February 2016

Publication Date:
22 March 2016 (eFirst)

Abstract

The reduction of bicyclic tetramates can be achieved with high levels of diastereocontrol, but small changes in the substitution of the bicyclic lactam system can lead to changes in the steric bias of the concave/convex system. The tetramates and pyroglutamates prepared in this work exhibited limited antibacterial activity.

Supporting Information