An efficient synthetic methodology was developed for direct formation of quinazolinones
with 2-nitromethyl substituent via 1,1-dichloro-2-nitroethene and anthranilamides.
This strategy provides an alternative for quinazolinones construction with merits
of proceeding in water, easy purification, and no addition of catalysts.
Key words
synthetic methodology - quinazolinones - 2-nitromethyl - 1,1-dichloro-2-nitroethene
- anthranilamides