Synlett 2016; 27(10): 1443-1449
DOI: 10.1055/s-0035-1561619
synpacts
© Georg Thieme Verlag Stuttgart · New York

The Total Synthesis of Hyperforin

Chi P. Ting
,
Thomas J. Maimone*
Further Information

Publication History

Received: 21 February 2016

Accepted after revision: 18 March 2016

Publication Date:
20 April 2016 (eFirst)

Abstract

Hyperforin has remained a popular and challenging synthetic target since its isolation over forty years ago. As a result, numerous synthetic strategies and ring-forming reactions have been developed to address its formidable molecular architecture. Herein we describe our contributions to this area resulting in a ten-step synthetic pathway enabled by a novel diketene annulation reaction and oxidative ring expansion strategy.

 
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