Synthesis 2016; 48(16): 2627-2636
DOI: 10.1055/s-0035-1561421
special topic
© Georg Thieme Verlag Stuttgart · New York

Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals

Shutao Sun
a  School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P. R. of China
,
Lei Liu*
a  School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P. R. of China
b  Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China   Email: leiliu@sdu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 15 January 2016

Accepted after revision: 23 February 2016

Publication Date:
07 April 2016 (eFirst)

Abstract

A highly enantioselective catalytic alkynylation of tetrahydroisoquinoline-based N-acyl hemiaminals has been developed. The method is simple and exhibits a broad scope with respect to both heterocycles and terminal alkynes, thus allowing for facile construction of a variety of enantiopure α-substituted tetrahydroisoquinolines.

Supporting Information

 
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