Synthesis 2016; 48(05): 644-652
DOI: 10.1055/s-0035-1561315
short review
© Georg Thieme Verlag Stuttgart · New York

Catalytic α-Alkylation/Reduction of Ketones with Primary Alcohols To Furnish Secondary Alcohols

Helena Lundberg*
The Department of Organic Chemistry, Stockholm University, The Arrhenius Laboratory, 10691 Stockholm, Sweden   Email: helena.lundberg@su.se   Email: hans.adolfsson@su.se
,
Hans Adolfsson*
The Department of Organic Chemistry, Stockholm University, The Arrhenius Laboratory, 10691 Stockholm, Sweden   Email: helena.lundberg@su.se   Email: hans.adolfsson@su.se
› Author Affiliations
Further Information

Publication History

Received: 04 December 2015

Accepted after revision: 09 December 2015

Publication Date:
11 January 2016 (online)


Abstract

The formation of secondary alcohol products via a tandem α-alkylation/transfer hydrogenation of ketones with primary alcohols is a little explored reaction with unrealized potential for green synthesis. This review covers the current literature in the field, including asymmetric versions of the reaction, and outlines future possibilities and challenges for the methodology.

1 Introduction

2 Formation of Racemic Alcohols

3 Formation of Enantiomerically Enriched Alcohols

4 Conclusions

 
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