Synlett 2015; 26(20): 2801-2805
DOI: 10.1055/s-0035-1560521
cluster
© Georg Thieme Verlag Stuttgart · New York

Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine

Rintaro Koga
Department of Chemistry, Faculty and Graduate School of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan   Email: torikai@chem.kyushu-univ.jp
,
Tohru Oishi
Department of Chemistry, Faculty and Graduate School of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan   Email: torikai@chem.kyushu-univ.jp
,
Kohei Torikai*
Department of Chemistry, Faculty and Graduate School of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan   Email: torikai@chem.kyushu-univ.jp
› Author Affiliations
Further Information

Publication History

Received: 28 July 2015

Accepted after revision: 13 October 2015

Publication Date:
29 October 2015 (online)

Dedicated to the memory of Prof. Tsutomu Katsuki for his enormous contribution to synthetic organic chemistry and encouragement to us.

Abstract

The diversity-oriented doubling strategy, which generates two 12-arylbenzoacridines from a single triarylmethanol precursor was developed to construct a library of drug candidates for the identification of biologically active compounds. Exploration of this 12-arylbenzoacridine library furnished a 4′-OH derivative as an estrogenic compound.

Supporting Information

 
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