Nucleophilic Catalysis in the Enantioselective Synthesis of α-Methylidene-δ-lactones
Received: 07 September 2015
Accepted after revision: 05 October 2015
06 November 2015 (eFirst)
A new method for the preparation of optically active α-methylidene-δ-lactones is presented. The developed strategy utilizes an intramolecular Rauhut–Currier reaction for a facile construction of the α-methylidene-δ-lactone framework. The reaction is catalyzed by a chiral phosphine and employs the principles of nucleophilic catalysis. It benefits from operational simplicity and uses readily available starting materials.