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Synthesis 2015; 47(24): 3947-3955
DOI: 10.1055/s-0035-1560470
DOI: 10.1055/s-0035-1560470
paper
Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3H)-ones
Further Information
Publication History
Received: 06 July 2015
Accepted after revision: 13 August 2015
Publication Date:
16 September 2015 (online)
Abstract
This study reports a simple and highly regioselective synthesis of a new series of 3,6-disubstituted 2-(methylsulfanyl)pyrimidin-4(3H)-ones, in which the 6-substituents are methyl or aryl groups and the 3-substituents are alkyl, allyl, phenyl, benzyl, or 2-phenylethyl groups. The products are obtained in good yields by cyclocondensation of the appropriate 4-substituted 4-methoxy-1,1,1-trichloroalk-3-en-2-ones with nonsymmetric 1-substituted 2-methylisothiourea sulfates under mild basic conditions.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560470.
- Supporting Information
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