Synthesis 2016; 48(02): 245-255
DOI: 10.1055/s-0035-1560361
paper
© Georg Thieme Verlag Stuttgart · New York

Fluorescently Labeled Amino Acids as Building Blocks for Bioactive Molecules

Daniela Häußler
Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany   Email: guetschow@uni-bonn.de
,
Michael Gütschow*
Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany   Email: guetschow@uni-bonn.de
› Author Affiliations
Further Information

Publication History

Received: 16 September 2015

Accepted after revision: 05 October 2015

Publication Date:
03 November 2015 (eFirst)

Abstract

A series of twelve fluorescently labeled amino acids were designed by assembling different coumarin, fluorescein, or nitrobenzo­furazan fluorophores with N-protected lysine or 2-aminopropionic acid. The synthesized amino acids were evaluated with regard to their spectroscopic properties. The easy introduction of the amino acids into peptides and peptidomimetics was exemplarily shown for one coumarin-labeled­ amino acid.

Supporting Information

 
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