Synlett 2015; 26(15): 2145-2150
DOI: 10.1055/s-0035-1560069
letter
© Georg Thieme Verlag Stuttgart · New York

Copper(II)-Catalyzed Oxidative Esterification of Substituted p-Cresols under Ligand- and Additive-Free Conditions

Zhong-Nan Zhang
School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, P. R. of China   Email: jyf@ecust.edu.cn
,
Jian-Gang Huang
School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, P. R. of China   Email: jyf@ecust.edu.cn
,
Jiao-Jiao Zhai
School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, P. R. of China   Email: jyf@ecust.edu.cn
,
Ying Guo
School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, P. R. of China   Email: jyf@ecust.edu.cn
,
Ya-Fei Ji*
School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, P. R. of China   Email: jyf@ecust.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 05 May 2015

Accepted after revision: 09 July 2015

Publication Date:
12 August 2015 (online)


Abstract

A facile, atom-economical, and efficient Cu(OAc)2-catalyzed oxidative esterification of substituted p-cresols was developed with ambient air as the terminal oxidant. This ligand- and additive-free esterification protocol allows an environmentally benign and reagent-economical access to benzyl esters.

Supporting Information