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Horm Metab Res 2016; 48(03): 174-177
DOI: 10.1055/s-0035-1559632
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Is Serum Serotonin Involved in the Bone Loss of Young Females with Anorexia Nervosa?

L. Maïmoun
1   Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHRU) Montpellier, Montpellier, France
2   PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214. 34295 Montpellier cedex 5, France
,
S. Guillaume
3   Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHRU Montpellier, UMI, INSERM, Montpellier, France
,
P. Lefebvre
4   Departement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
,
P. Philibert
5   Departement de Biochimie et d’Hormonologie, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
,
H. Bertet
6   Unité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
,
M.-C. Picot
6   Unité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
7   CIC INSERM, Hôpital Gui de Chauliac, CHRU Montpellier, Montpellier, France
,
P. Courtet
3   Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHRU Montpellier, UMI, INSERM, Montpellier, France
,
D. Mariano-Goulart
1   Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHRU) Montpellier, Montpellier, France
2   PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214. 34295 Montpellier cedex 5, France
,
E. Renard
4   Departement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
7   CIC INSERM, Hôpital Gui de Chauliac, CHRU Montpellier, Montpellier, France
8   Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier 1 et 2, Montpellier, France
,
C. Sultan
9   Unité d’Endocrinologie et Gynécologie Pédiatrique, Département de Pédiatrie, Hôpital Arnaud de Villeneuve, CHRU Montpellier et UMI, Montpellier, France
› Author Affiliations
Further Information

Publication History

received 27 March 2015

accepted 08 July 2015

Publication Date:
29 September 2015 (online)

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Abstract

Recent experimental data suggest that circulating serotonin interacts with bone metabolism, although this is less clear in humans. This study investigated whether serum serotonin interferes with bone metabolism in young women with anorexia nervosa (AN), a clinical model of energy deprivation. Serum serotonin, markers of bone turnover [osteocalcin (OC), procollagen type I N-terminal propeptide (PINP), type I-C telopeptide breakdown products (CTX)], leptin, soluble leptin receptor (sOB-R), and insulin-like growth factor-1 (IGF-1) and its binding protein (IGFBP-3) were assessed. Whole body, spine, hip, and radius areal bone mineral density BMD (aBMD) were assessed by dual-energy X-ray absorptiometry in 21 patients with AN and 19 age-matched controls. Serum serotonin, leptin, IGF-1, IGFBP-3, OC, PINP, and aBMD at all sites, radius excepted, were significantly reduced in AN whereas CTX and sOB-R were increased compared with controls. Serum serotonin levels were positively correlated with weight, body mass index, whole body fat mass, leptin, and IGF-1, and negatively with CTX for the entire population. Low serum serotonin levels are observed in patients with AN. Although no direct link between low serum serotonin levels and bone mass was identified in these patients, the negative relationship between serotonin and markers of bone resorption found in all population nevertheless suggests the implication of serotonin in bone metabolism. Impact of low serum serotonin on bone in AN warrants further studies.

Key words

anorexia nervosa - bone demineralization - serotonin - bone remodeling markers - bone mineral density
 

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