Clinical Evaluation and Management of Inflammatory Myopathies

Sameer Chhibber; Anthony A. Amato

doi:10.1055/s-0035-1558980

Seminars in Neurology, Table of Contents

Semin Neurol 2015; 35(04): 347-359
DOI: 10.1055/s-0035-1558980

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Clinical Evaluation and Management of Inflammatory Myopathies

Sameer Chhibber

¹Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

,

Anthony A. Amato

²Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

› Author Affiliations

Abstract

The idiopathic inflammatory myopathies are classified into four distinct subtypes: dermatomyositis, polymyositis, inclusion body myositis, and immunomediated necrotizing myopathy. These subtypes are clinically, histologically, and pathogenically distinct. Dermatomyositis, polymyositis, and necrotizing myopathy generally respond to immunotherapy, whereas inclusion body myositis does not. In this review, the authors focus on the clinical evaluation and management of idiopathic inflammatory myopathies and highlight recent therapeutic studies and the evolving role of myositis-specific antibodies.

Keywords

inflammatory myositis - inclusion body myositis - dermatomyositis - immunomediated necrotizing myopathy

Full Text

References

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