Planta Medica Letters 2015; 2(01): e73-e77
DOI: 10.1055/s-0035-1558261
Letter
Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Norhopene Triterpenoids from the Bark of Exothea paniculata from Abaco Island, Bahamas

Bhuwan K. Chhetri
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA
,
Noura S. Dosoky
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA
,
William N. Setzer
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA
› Author Affiliations
Further Information

Publication History

received 25 September 2015
revised 25 September 2015

accepted 21 October 2015

Publication Date:
21 December 2015 (online)

Abstract

Bioactivity-directed preparative chromatography of the cytotoxic crude dichloromethane bark extract of Exothea paniculata has yielded two new cytotoxic norhopene triterpenoids, exotheol A and exotheol B. The structures were determined by nuclear magnetic resonance and high-resolution mass spectrometry and were found to be potently cytotoxic to MCF-7 and 5637 cells in vitro.