Planta Med 2016; 82(03): 244-249
DOI: 10.1055/s-0035-1558141
Natural Product Chemistry & Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Metabolite Profiling and Comparison of Bioactivity in Antrodia cinnamomea and Antrodia salmonea Fruiting Bodies

Chieh-Yin Chen
1   Department of Forestry, National Chung-Hsing University, Taichung, Taiwan
2   Experimental Forest, College of Bio-Resources and Agriculture, National Taiwan University, Nantou, Taiwan
Shih-Chang Chien
3   The Experimental Forest Management Office, National Chung-Hsing University, Taichung, Taiwan
Nai-Wen Tsao
1   Department of Forestry, National Chung-Hsing University, Taichung, Taiwan
Chiem-Sing Lai
1   Department of Forestry, National Chung-Hsing University, Taichung, Taiwan
Ya-Yun Wang
1   Department of Forestry, National Chung-Hsing University, Taichung, Taiwan
Wen-Wei Hsiao
2   Experimental Forest, College of Bio-Resources and Agriculture, National Taiwan University, Nantou, Taiwan
Fang-Hua Chu
4   School of Forestry and Resource Conservation, National Taiwan University, Taipei, Taiwan
Yueh-Hsiung Kuo
5   Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan
6   Department of Biotechnology, Asia University, Taichung, Taiwan
Sheng-Yang Wang
1   Department of Forestry, National Chung-Hsing University, Taichung, Taiwan
7   Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan, Taiwan
› Author Affiliations
Further Information

Publication History

received 07 July 2015
revised 02 September 2015

accepted 11 September 2015

Publication Date:
09 November 2015 (online)


Antrodia cinnamomea is a precious edible mushroom endemic to Taiwan that has been claimed to have significant health promotion activities. Antrodia salmonea is a new species of the genus Antrodia. In this study, we compared the metabolites and bioactivity of A. cinnamomea and A. salmonea fruiting bodies. The volatiles of A. cinnamomea and A. salmonea were characterized and 3,4,5-trimethoxybenzaldehyde was found to be the most abundant compound in A. cinnamomea; the other abundant compounds were δ-guaiene, isolongifolene, 1-octen-3-ol, 4-terpinenol, α-guaiene, and p-cymene. In A. salmonea, the main volatiles were α-cedrene, 1-octen-3-ol, D-limonene, cadinadiene, germacrene D, isolongifolene, and α-muurolene. Furthermore, five ergostane-type triterpenoids and two lanostane-type triterpenoids were selected as index compounds characterizing A. cinnamomea and A. salmonea extracts. The content of each compound varied between the two species. (R,S)-antcin B was the most abundant compound in A. cinnamomea fruiting bodies (75.18 ± 0.11 µg/mg). However, (R,S)-antcin C (184.85 ± 0.96 µg/mg) was the major triterpenoid in the A. salmonea fruiting body. Furthermore, two compounds, antcin M and methyl antcinate K, were only present in the A. salmonea fingerprint; therefore, antcin M and methyl antcinate K may be important for distinguishing between A. cinnamomea and A. salmonea fruiting bodies. Finally, examination of anti-inflammation activity and cytotoxicity showed that A. salmonea had more anti-inflammatory activity than A. cinnamomea; however, A. salmonea was more cytotoxic than A. cinnamomea. In conclusion, the composition and bioactivity of the fruiting bodies of A. cinnamomea and A. salmonea varies. Therefore, it is recommended that further toxicological evaluation and investigation of the biological activity of A. salmonea is carried out to ensure its safe and efficacious use as an alternative to A. cinnamomea.

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