Planta Med 2016; 82(01/02): 32-45
DOI: 10.1055/s-0035-1558086
Reviews
Georg Thieme Verlag KG Stuttgart · New York

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

Shahpour Khangholi
Tissue Culture Engineering Laboratory, Universiti Teknologi Malaysia (UTM), Malaysia
,
Fadzilah Adibah Abdul Majid
Tissue Culture Engineering Laboratory, Universiti Teknologi Malaysia (UTM), Malaysia
Institute of Bio-products Development, Universiti Teknologi Malaysia (UTM), Malaysia
,
Najat Jabbar Ahmed Berwary
College of Medicine, Hawler Medical University, Erbil, Iraq
,
Farediah Ahmad
Department of Biochemistry, Faculty of Sciences, Universiti Teknologi Malaysia (UTM), Malaysia
,
Ramlan Bin Abd Aziz
Institute of Bio-products Development, Universiti Teknologi Malaysia (UTM), Malaysia
› Author Affiliations
Further Information

Publication History

received 30 June 2014
revised 25 June 2015

accepted 20 August 2015

Publication Date:
09 November 2015 (eFirst)

Abstract

Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.