Pharmacopsychiatry 2015; 25 - A14
DOI: 10.1055/s-0035-1557952

The sedative burden

B Fay 1, J Seifert 1, N T Strueven 1, K Wenzel-Seifert 1, E Haen 1
  • 1Clinical Pharmacology, Department of Psychiatry and Psychotherapy, University

Somnolence among the eldery is a common adverse drug event (ADR) in clinical practice. Preventing the aged from this ADR a tool will be developed to calculate the sedative burden of a medication. Methods: Medical files of somnolent patients (n = 22) and non-somnolent patients (n = 107) are compared. The files are provided from an observational trial conducted at the BKH Regensburg (inclusion criteria ≥ 65 years). The number of antipsychotics, interactions, affinity to H1-receptor, dosages of antipsychotics are supposed to be risk factors. Proofing the correlation between risk factors and somnolence Χ²-Test and t-tests (SPSS®) are performed. Results: The probability to suffer from a sedation is higher, if the patient takes at least 2 antipsychotics (somnolent patients 40.9% vs. 18.7% non-somnolent patients) (Χ²-Test p < 0,083). Sedation risk is also higher with an increasing number of drugs with affinity to the H1-receptor. (Χ²-test p < 0,277). To obtain the final sedative burden a classification of the h1-receptor affinity and a larger number of patients are necessary. Risk factors will be ranked by performing a multivariate analysis. Results will be presented at the AGNP.