Pharmacopsychiatry 2015; 25 - A1
DOI: 10.1055/s-0035-1557939

Adverse drug reactions: vascular parkinsonism and sedation – a pharmacokinetic and pharmacodynamic evaluation from the German Pharmacovigilance project AMSP

I Adamovic 1, A Sagebiel 1, R Grohmann 2, S Toto 3, D Degner 1
  • 1Department of Psychiatry and Psychotherapy, University of Göttingen, Germany
  • 2Department of Psychiatry and Psychotherapy, LMU München, Germany
  • 3Department of Psychiatry, Social Psychiatry and Psychotherapy, MHH Hannover, Germany

We present a case of a vascular parkinsonism and severe sedation associated with quetiapine, aripiprazole and valproic acid. The patient was suffering from a bipolar affective disorder. Pharmacokinetic and pharmacodynmic aspects and interaction risks especially in elderly patients were demonstrated. These adverse drug reactions were registrated from the German pharmacovigilance study “Arzneimittelsicherheit in der Psychiatrie”(AMSP).