Planta Medica Letters 2015; 2(01): e28-e30
DOI: 10.1055/s-0035-1557793
Letter
Georg Thieme Verlag KG Stuttgart · New York

Rottlerin Derivatives and Other Compounds from Mallotus philippinensis Fruits and Their Potential Antimycobactrial Activity

Rima Bharadwaj
1  Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India
,
Ashish A. Chinchansure
1  Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India
,
Roshan R. Kulkarni
1  Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India
,
Manisha Arkile
2  Combi Chem-Bio Resource Centre, CSIR-National Chemical Laboratory, Pune, India
,
Dhiman Sarkar
2  Combi Chem-Bio Resource Centre, CSIR-National Chemical Laboratory, Pune, India
,
Swati P. Joshi
1  Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India
› Author Affiliations
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Publication History

received 14 May 2015
revised 30 June 2015

accepted 30 June 2015

Publication Date:
04 August 2015 (online)

Abstract

The methanolic extract of the fruits of Mallotus philippinensis afforded 13 compounds, 7,11-diketo-lanost-3-ol (1, as acetate), lanosta-8-ene-3β-ol (2, as acetate), pregnenolone (3, as acetate), trans-chalcone (4), kamalachalcone E (5), oleanolic acid (6), gallic acid (7), kaempferol (8), myricetin (9), 1-(5,7-dihydroxy-2,2,6-trimethyl-2 H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one (10), 4′-hydroxyisorottlerin (11), rottlerin (12), and shikimic acid (13). Compound 1 was isolated as a new natural product and its structure was elucidated by 1D and 2D nuclear magnetic resonance analyses including heteronuclear single quantum correlation, heteronuclear multiple-bond correlation, correlation spectroscopy, and nuclear Overhauser effect spectroscopy experiments. All of the isolated compounds were evaluated for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra. Compounds 11 and 12 exhibited promising inhibitory activity with IC50 values of 0.89 ± 0.33 µg/mL (MIC 2.06 ± 0.41 µg/mL) and 7.59 ± 0.42 µg/mL (MIC 11.56 ± 0.35 µg/mL), respectively.

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