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Journal of Pediatric Neurology 2008; 06(03): 277-281
DOI: 10.1055/s-0035-1557459
DOI: 10.1055/s-0035-1557459
Case Report
A novel therapeutic intervention for postencephalitic mental retardation
Subject Editor:
Further Information
Publication History
19 October 2007
18 January 2008
Publication Date:
30 July 2015 (online)

Abstract
Viral encephalitis is often followed by cognitive sequelae including intellectual decline whose pathophysiology remains obscure till date. Based on recent laboratory studies implicating the cholinergic system in viral encephalitis, the authors postulate the hypothesis that cholinergic deficit might account for some of the cognitive sequelae in at least some types of viral encephalitis, which might be benefited by central acetyl cholinesterase inhibitors. The case of an adolescent with postencephalitic intellectual decline responding robustly to donepezil is presented.