Abstract
The aim of this study was to determine type, prevalence and risk factors for infectious
diseases in internationally adopted children. The number of internationally adopted
children is still increasing and the countries of origin change with time. Regular
reassessment of the epidemiology of infectious diseases is essential in order to recommend
appropriate screening and treatment for these children. A retrospective cohort study
was conducted between 01/01/1998 and 12/31/2001. Of 552 children evaluated, 77% were
females. Median age was 13 months. Children originated mainly from China (n = 319, 57.8%) and other Asian countries (n = 112, 20.3%). Overall, 105 children (19.0%) were found to have at least one type
of infection diagnosed on initial screening. In our cohort, 57 of 342 children (16.7%)
were infected with one or more pathogenic intestinal parasites; the most common was
Giardia lamblia, found in 44 of 342 tested children (12.8%). Increasing age was associated with an
increased risk of parasitic infection, with children 12–24 months (adjusted OR: 7.9;
95% CI: 2.6–24.5), and children > 24 months (adjusted OR: 25.3; 95% CI: 7.7–83.1)
being significantly more at risk than children < 12 months. Stool cultures were positive
in 13 of 159 tested children (8.2%). Eleven percent (41 of 371) of children tested
had a tuberculin skin testing (TST) reaction ≥ 10 mm. Eastern European (adjusted OR:
3.5; 95% CI: 1.1–11.1) and Latin American (adjusted OR: 4.9, 95% CI: 1.5–15.8) children
were more likely to have a positive TST. Serological evidence of active or chronic
hepatitis B infection was found in six children (1.0%). Two children had syphilis
and one had hepatitis A. All children screened for hepatitis C and HIV were negative.
Our study shows a high intestinal parasite infection rate, high rates of latent tuberculosis
and lower hepatitis B rates than previously reported. If undetected, some of these
diseases may have serious long-term consequences. Screening should be performed for
all internationally adopted children at the time of arrival into the adoptive home.
Keywords
Adoption - screening - tuberculosis - intestinal parasites - hepatitis B
