J Pediatr Infect Dis 2007; 02(03): 157-161
DOI: 10.1055/s-0035-1557040
Original Article
Georg Thieme Verlag KG Stuttgart – New York

Clinical use of the serum bactericidal test to guide therapy in pediatric patients with penicillin and cephalosporin-nonsusceptible pneumococcal meningitis

Yu-Chen Lin
a  Department of Pediatrics, LongCyuan Veterans Hospital, Pingtung, Taiwan
,
Ruay-Shyang Wang
b  Department of Pediatrics, YongKang Veterans Hospital, Tainan, Taiwan
,
I-Fei Huang
c  Department of Pediatrics, Veterans General Hospital, Kaohsiung, Taiwan
d  National Yang-Ming University, Taipei, Taiwan
,
Kai-Sheng Hsieh
c  Department of Pediatrics, Veterans General Hospital, Kaohsiung, Taiwan
,
Christine C. Chiou
c  Department of Pediatrics, Veterans General Hospital, Kaohsiung, Taiwan
d  National Yang-Ming University, Taipei, Taiwan
› Author Affiliations

Subject Editor:
Further Information

Publication History

22 December 2007

06 April 2007

Publication Date:
28 July 2015 (online)

Abstract

We report four pediatric patients with penicillin and cephalosporin-nonsusceptible pneumococcal meningitis who were treated with dexamethasone for the first four days of vancomycin therapy. Serum and cerebrospinal fluid bactericidal tests were performed to measure in vivo activity of vancomycin in the presence of dexamethasone. Favorable outcome was achieved in all four patients.