Int J Angiol 2015; 24(04): 275-277
DOI: 10.1055/s-0035-1556841
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Any Degree of Mitral Regurgitation Found during Invasive Ventriculography is Associated with All-Cause Mortality

Mohammad Reza Movahed
1   CareMore, Cardiology, Tucson, Arizona
2   Division of Cardiology, Department of Medicine, University of Arizona Sarver Heart Center, Tucson, Arizona
Kusum Lata
2   Division of Cardiology, Department of Medicine, University of Arizona Sarver Heart Center, Tucson, Arizona
› Author Affiliations
Further Information

Publication History

Publication Date:
15 July 2015 (online)


Background Using a large database of patients who underwent cardiac catheterization for clinical reasons, we evaluated any association between reported degrees of mitral regurgitation (MR) found during ventriculography, and all-cause mortality.

Method Using retrospective angiographic data (collected from the years 1993–1997) from 1,771 patients of the VA Long Beach Health Care System with documented ventriculography, we evaluated any association between various degrees of MR and all-cause mortality. We performed uni- and multivariant analysis, adjusting for age and ejection fraction.

Results Any degree of MR was associated with all-cause mortality. Total mortality was 20.2% (296/1,465) in patients with no MR versus 32.7% in patients with mild MR (64/196), p < 0.001. Similar to mild MR, any degree of MR was independently associated with all-cause mortality (all MR, 35.1%, [108/306] vs. no MR, 20.2% [296/1,465], p < 0.001). After adjustment for age and comorbidities, any degree of MR remained independently associated with all-cause mortality (multivariate adjusted odds ratio, 1.7; confidence interval, 1.2–2.3; p < 001).

Conclusion The presence of any MR documented on invasive ventriculography is associated with increased total mortality independent of age or ejection fraction. Our finding suggests that even mild MR has negative prognostic significance.

  • References

  • 1 Grigioni F, Enriquez-Sarano M, Zehr KJ, Bailey KR, Tajik AJ. Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation 2001; 103 (13) 1759-1764
  • 2 Baskett RJ, Exner DV, Hirsch GM, Ghali WA. Mitral insufficiency and morbidity and mortality in left ventricular dysfunction. Can J Cardiol 2007; 23 (10) 797-800
  • 3 Moazami N, Diodato MD, Moon MR , et al. Does functional mitral regurgitation improve with isolated aortic valve replacement?. J Card Surg 2004; 19 (5) 444-448
  • 4 Studies of left ventricular dysfunction (SOLVD)—rationale, design and methods: two trials that evaluate the effect of enalapril in patients with reduced ejection fraction. Am J Cardiol 1990; 66 (3) 315-322
  • 5 The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991; 325 (5) 293-302
  • 6 Amigoni M, Meris A, Thune JJ , et al. Mitral regurgitation in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: prognostic significance and relation to ventricular size and function. Eur Heart J 2007; 28 (3) 326-333