Planta Med 2015; 81 - PY4
DOI: 10.1055/s-0035-1556534

Two new lactams from the hulled seeds of Coix lachryma-jobi Var. ma-yuen

AR Han 1, U Kang 1, YS Kil 1, EK Seo 1
  • 1College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120 – 750, Korea

Two new lactams, coixspirolactam F ((2R,3R)-(+)-2-octanoate-spiro[furan-3(2H),3'-[3H]indole]-2',5(1'H,4H)-dione; 1) and coixspirolactam G ((2R,3R)-(+)-6'-hydroxy-2-octanoate-spiro[furan-3(2H),3'-[3H]indole]-2',5(1'H,4H)-dione; 2) were isolated from the hulled seeds of Coix lachryma-jobi L. var. ma-yuen (ROM. CAILL.) STAPF (Gramineae). Their structures were elucidated by physical and spectroscopic data analysis, including 1D and 2D NMR, ESI-MS, and CD experiments.