Discovery of 20-hydroxyecdysone from Xerophyllum asphodeloides (Turkey beard)

D Tian; JR Porter

doi:10.1055/s-0035-1556516

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Planta Med 2015; 81 - PX72
DOI: 10.1055/s-0035-1556516

Discovery of 20-hydroxyecdysone from Xerophyllum asphodeloides (Turkey beard)

D Tian ¹, JR Porter ¹

¹Program in Pharmacognosy, Department of Chemistry & Biochemistry, University of the Sciences, Philadelphia, PA 19104 USA

Congress Abstract

Ecdysterone (20-hydroxyecdysone) is one of the key hormones in insects and crustaceans. A number of higher plants contain ecdysteroids. Phytoecdysteroids play a role in the chemical defenses of plants. We report the discovery of 20-hydroxyecdysone 1 from Xerophyllum asphodeloides L. (Nutt.) collected from the NJ pinelands with a brine shrimp assay-guided fractionation approach. The isolated 20-hydroxyecdysone showed modest activity (LD₅₀ 12.5 µg/mL) in the brine shrimp assay. The spectroscopic data agree with the reported data. This is the first report of the discovery of 20-hydroxyecdystone in X. asphodeloides.