Planta Med 2015; 81 - PX68
DOI: 10.1055/s-0035-1556512

Delphatisine D and chrysotrichumine A, two rare new diterpene alkaloids from Delphinium chrysotrichum

YQ He 1, LM West 2
  • 1Department of Applied Chemistry, Xi'an University of Technology, Xi'an, Shaanxi 710054, P. R. China
  • 2Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, USA

Chemical investigations of the Tibetan folk medicine Delphinium chrysotrichum resulted in the isolation of two new diterpenoid alkaloids, delphatisine D (1) and chrysotrichumine A (2), together with eleven known compounds including one sesquiterpenoid, 3β,6α-dlphydroxysclareollda (3) and ten diterpenoid alkaloids. Compund 1 is a rare isoatisine-type alkaloid from genus Delphinium and is the C-15 epimer of spiramine C which bearing an internal carbinolamine ether linkage (N-C-O-C) between C-7 and C-20. Compound 2 is a rare natural C19-diterpenoid alkaloid possessing a nitrone group between C-17 and C-19. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compound 3 is a sesquiterpenoid first isolated from this genus.