Two new potent antimalarial alkaloids, cripowellins C and D, from the swamp Lily crinum erubescens

Malaria is a neglected tropical disease that has a disproportionate effect in poor and underdeveloped countries. As part of our ongoing search for new antimalarial compounds, an extract of the Swamp Lily Crinum erubescens was selected due to its potent antimalarial activity. Bioassay guided fractionation yielded four potent antimalarial compounds. Compounds 1 and 2 were identified as the known compounds cripowellins A and B, while compounds 3 and 4 were determined to be the new compounds cripowellins C and D. Structures were elucidated using various 1 and 2-dimensional NMR techniques. The isolation and structure elucidation of the cripowellins and their biological data will be presented.