Alkaloids constituents from the fruits of Piper nigrum L. and their anti-inflammation activity

BM Lee; NT Quynh Mai; JA Kim; BS Min

doi:10.1055/s-0035-1556495

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Planta Med 2015; 81 - PX51
DOI: 10.1055/s-0035-1556495

Alkaloids constituents from the fruits of Piper nigrum L. and their anti-inflammation activity

BM Lee ¹, NT Quynh Mai ¹, JA Kim ², BS Min ¹

¹College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712 – 702, Korea
²College of Pharmacy, Kyungpook National University, Daegu 702 – 701, Korea

Congress Abstract

Eight alkaloids, piperine, pellitorine, isopiperolein B, Pyroperine, dehydropipernonaline, 1-Cinnamoyl piperidine, dihydopiperine, retrofractamide A, along with 3,4 methylenedioxy cinnamaldehyde, were isolated from the fruits of Piper nigrum L.. Their structures were elucidated by spectroscopic methods. In vitro activity assay showed that pellitorine, isopiperolein B, retrofractamide A and dehydropipernonaline presented remarkable activity on lipopolysaccharide (LPS)-induce NO release.