Planta Med 2015; 81 - PX21
DOI: 10.1055/s-0035-1556465

Withanolides from Physalis coztomatl

H Zhang 1, CM Cao 1, RJ Gallagher 1, VW Day 2, K Kindscher 3, BN Timmermann 1
  • 1Department of Medicinal Chemistry, School of Pharmacy
  • 2The Small-Molecule X-ray Crystallography Laboratory
  • 3Kansas Biological Survey, University of Kansas, Lawrence, KS 66047

Six new withanolides (1 – 6), as well as the known physachenolide D (7) and withanoside VI (8), were isolated from the aerial parts of Physalis coztomatl (Mociño & Sessé) Ex Dunal (Solanaceae). Structural elucidations of 1 – 6 were achieved through spectroscopic techniques including 2D NMR, while the structure of 1 was confirmed by X-ray crystallography. 13C NMR analysis revealed that coagulansin A in the literature contains a 17α-hydroxy rather than the reported 17β-hydroxy functionality.