Planta Med 2015; 81 - PT43
DOI: 10.1055/s-0035-1556421

Sordaricins and podosporins from Sordaria araneosa

JA Clement 1, JM Sigmund 1, MA Goetz 1
  • 1Natural Products Discovery Institute, Baruch S. Blumberg Institute, Doylestown PA, 18902, USA

During the course of exploring the antifungal constituents produced by the coprophilous fungus Sordaria araneosa, two new congeners (1 and 2) of podosporin A were isolated, along with podosporin A (3), sordarin, and hypoxysordarin. Compounds 1 and 2 showed weak activity against Staphylococcus aureus, while 3 was not active. While sordarin and hypoxysordarin were active against Candida albicans, 1-3 were not active. The compounds were characterized by 1D and 2D NMR analysis and high resolution MS analysis.