Activity comparison of cyclic lipodepsipeptides from mammalian microbiome bacterial sources

JL Motley; CA Mitchell; T Culver; J King; SL Nimmo; DR Powell; RH Cichewicz

doi:10.1055/s-0035-1556417

Planta Medica, Table of Contents

Activity comparison of cyclic lipodepsipeptides from mammalian microbiome bacterial sources

JL Motley ¹, CA Mitchell ¹, T Culver ¹, J King ¹, SL Nimmo ¹, DR Powell ¹, RH Cichewicz ¹

¹Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Pkwy, Norman, OK 73019

Abstract

Cyclic lipodepsipeptides (CLDP) are produced by bacteria and have been studied extensively for their antimicrobial activities and wetting properties. Bacteria derived from opportunistically sampled mammals, including opossum, skunk, raccoon, boar, and deer, in Oklahoma were cultured and shown to produce CLDPs including viscosin, serratiamycin, and surfactin. Two dimensional NMR studies and MS analysis lead to 3 new serrawettin W2 analogues. Their activities against several biological targets were assessed.