Planta Med 2015; 81 - PT39
DOI: 10.1055/s-0035-1556417

Activity comparison of cyclic lipodepsipeptides from mammalian microbiome bacterial sources

JL Motley 1, CA Mitchell 1, T Culver 1, J King 1, SL Nimmo 1, DR Powell 1, RH Cichewicz 1
  • 1Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Pkwy, Norman, OK 73019

Cyclic lipodepsipeptides (CLDP) are produced by bacteria and have been studied extensively for their antimicrobial activities and wetting properties. Bacteria derived from opportunistically sampled mammals, including opossum, skunk, raccoon, boar, and deer, in Oklahoma were cultured and shown to produce CLDPs including viscosin, serratiamycin, and surfactin. Two dimensional NMR studies and MS analysis lead to 3 new serrawettin W2 analogues. Their activities against several biological targets were assessed.