Planta Med 2015; 81 - PT38
DOI: 10.1055/s-0035-1556416

Isolation and structure elucidation of a possible ant trail pheromone, from epothilone B producing fermentations of Sorangium cellulosum

D Benigni 1, D Weaver 1, J Baumes 1, J Karten 2, M Kosmoski 1, L Phillips 3
  • 1Bristol-Myers Squibb, Global Manufacturing and Supply, Syracuse, New York
  • 2Bristol-Myers Squibb Research and Development, New Brunswick, New Jersey
  • 3Research and Development, Lawrenceville, New Jersey

Sorangium cellulosum is a myxobacteria producing epothilone B. During the development of the process to purify epothilone B from fermentation of Sorangium cellulosum we identified a possible ant trail pheromone. The initial detection, isolation and structure elucidation of S-3,4-dihydro-8-hydroxy-3,5,7-trimethylisocoumarin will be presented as well as literature regarding its biosignificance.