Planta Med 2015; 81 - PQ29
DOI: 10.1055/s-0035-1556363

Detection of halogenated tryamine and tyrosine derivatives in extracts of Algoa Bay ascidians

CL Bromley 1, A Raab 2, D Beukes 3, J Feldman 2, M Jaspars 2, MT Davies-Coleman 3
  • 1Rhodes University, Grahamstown, South Africa
  • 2Marine Biodiscovery Centre, Department of Chemistry, College of Physical Sciences, University of Aberdeen, Old Aberdeen, AB24 3UE, Scotland (UK)
  • 3University of the Western Cape, Cape Town, South Africa

The crude organic extracts of ascidian species collected from Algoa Bay, South Africa were analysed using liquid chromatography with parallel inductively coupled plasma mass spectrometry/electrospray mass spectrometry (LC-ICP-MS/ESI-MS). The data obtained was used to detect a number of brominated and iodinated tyramine and tyrosine derivatives with in the ascidian extracts establishing this method as a powerful tool for the dereplication of halogenated metabolites in complex mixtures.