Planta Med 2015; 81 - PQ15
DOI: 10.1055/s-0035-1556349

Sesterterpenes and a nortriterpene saponin from the sponge Clathria gombawuiensis

JK Woo 1, CK Kim 1, SH Kim 1, H Kim 2, CH Ahn 2, DC Oh 1, KB Oh 2, J Shin 1
  • 1Natural Products Research Institute, College of Pharmacy, Seoul National University, Gwanak, Seoul 151 – 742, Korea
  • 2Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Gwanak, Seoul 151 – 921, Korea

Six new sesterterpene metabolites (1 – 6) were isolated from the Korean marine sponge Clathria gombawuiensis. On the basis of the results of combined spectroscopic analyses, gombaspiroketals A-C (1 – 3), tetracyclic sesterterpenes of a novel skeletal class, the structures of phorone B (4) and ansellone C (5) were determined to be the phorone and ansellone classes, respectively, whereas the saponin gombaside A (6) was a nortriterpene sodium O-sulfonato-glucuronide of the rare 4,4,14-trimethylpregnane class. Six compounds exhibited moderate cytotoxicity and antibacterial activity.